Acetamide,2,2,2-trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

名称

[ CAS 号 ]:
26195-65-3

[ 英文名 ]:
Acetamide,2,2,2-trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

[英文别名 ]:

物理化学性质

[ 密度 ]:
1.36g/cm3

[ 沸点 ]:
681.3ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₂F₃NO₆

[ 分子量 ]:
453.40800

[ 闪点 ]:
365.8ºC

[ 精确质量 ]:
453.14000

[ PSA ]:
83.09000

[ LogP ]:
3.80490

[ 蒸汽压 ]:
2.05E-18mmHg at 25°C

[ 折射率 ]:
1.555

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0910000

CHEMICAL NAME :: Colchicine, 17,17,17-trifluoro-

CAS REGISTRY NUMBER :: 26195-65-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H22-F3-N-O6

MOLECULAR WEIGHT :: 453.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMVXFFF NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 844 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 456 ug/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

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