利帕西泮

利帕西泮用途

利帕西泮(Cl-683)是一种潜在的抗焦虑剂。利帕西泮也是一种吡唑啉二氮平酮衍生物,具有抗焦虑作用[1]。

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利帕西泮名称

[ CAS 号 ]:
26308-28-1

[ 中文名 ]:
利帕西泮

[ 英文名 ]:
Ripazepam

[英文别名 ]:

Ripazepamum [INN-Latin]
RIPAZEPAM
CI-683
Cl-683
Pyrazapon
Ripazepam [USAN:INN]

利帕西泮生物活性

[ 描述 ]:

利帕西泮(Cl-683)是一种潜在的抗焦虑剂。利帕西泮也是一种吡唑啉二氮平酮衍生物,具有抗焦虑作用[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

利帕西泮物理化学性质

[ 密度 ]:
1.28g/cm3

[ 沸点 ]:
466.6ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₁₆N₄O

[ 分子量 ]:
268.31400

[ 闪点 ]:
236ºC

[ 精确质量 ]:
268.13200

[ PSA ]:
59.28000

[ LogP ]:
1.57450

[ 蒸汽压 ]:
6.97E-09mmHg at 25°C

[ 折射率 ]:
1.664

利帕西泮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR0100000

CHEMICAL NAME :: Pyrazolo(4,3-e)(1,4)diazepin-5(1H)-one, 4,6-dihydro-1-ethyl-3-methyl-8-phenyl-

CAS REGISTRY NUMBER :: 26308-28-1

LAST UPDATED :: 199703

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H16-N4-O

MOLECULAR WEIGHT :: 268.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 81900 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,178,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,157,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,157,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,157,1996

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利帕西泮安全信息

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

利帕西泮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%