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羧基二羟鬼笔毒肽

羧基二羟鬼笔毒肽用途

法拉西定是一种天然的真菌毒素,首先从死帽蘑菇中分离出来。Phalacidin与丝状肌动蛋白(F-actin)结合,类似于phalloidin(项目编号18039),但包含用于偶联反应的羧基。

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羧基二羟鬼笔毒肽名称

[ CAS 号 ]:
26645-35-2

[ 中文名 ]:
类鬼笔毒环肽

[ 英文名 ]:
phallacidin

[英文别名 ]:

PHALLICIDIN
PHALLACIDIN
MFCD00063359

羧基二羟鬼笔毒肽生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

羧基二羟鬼笔毒肽物理化学性质

[ 密度 ]:
1.54 g/cm3

[ 沸点 ]:
1435.2ºC

[ 分子式 ]:
C₃₇H₅₀N₈O₁₃S

[ 分子量 ]:
846.90400

[ 闪点 ]:
821.8ºC

[ 精确质量 ]:
846.32200

[ PSA ]:
354.22000

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.683

[ 储存条件 ]:
-20°C

羧基二羟鬼笔毒肽MSDS

详细MSDS(安全技术说明书)

羧基二羟鬼笔毒肽毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GT8943000

CHEMICAL NAME :: cyclic(L-Alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy -L-leucyl-L-valyl-ery thro-3-hydroxy- D-alpha-aspartyl-L-cysteinyl-cis-4-hydroxy-L-prolyl) cyclic (2-6)-sulfide

CAS REGISTRY NUMBER :: 26645-35-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C37-H50-N8-O13-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRBCAI CRC Critical Reviews in Biochemistry. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1972- Volume(issue)/page/year: 5,185,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,2142,1972

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羧基二羟鬼笔毒肽安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S22;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
GT8943000

[ 危险类别 ]:
6.1(a)

羧基二羟鬼笔毒肽文献

Intestinal epithelial cytoskeleton selectively constrains lumen-to-tissue migration of neutrophils.

Am. J. Physiol. 271(1 Pt 1) , C312-20, (1996)

Migration of neutrophils (polymorphonuclear leukocytes; PMN) across polarized epithelia is asymmetrical: basolateral-to-apical (physiologically directed) migration is far more efficient than migration...

A concept study on identification and attribution profiling of chemical threat agents using liquid chromatography-mass spectrometry applied to Amanita toxins in food.

Forensic Sci. Int. 221(1-3) , 44-9, (2012)

Accidental or deliberate poisoning of food is of great national and international concern. Detecting and identifying potentially toxic agents in food is challenging due to their large chemical diversi...

Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro.

Biochem. Biophys. Res. Commun. 217(2) , 466-74, (1995)

The transmembrane integrins have been shown to interact with the cytoskeleton via noncovalent binding between cytoplasmic domains (CDs) of integrin beta chains and various actin binding proteins withi...

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