氯贝胺

氯贝胺用途

氯原纤维是一种口服活性的多氯苯氧基异丁基降血脂剂。氯原纤维具有弱毒性和显著的低胆固醇血症和低甘油血症活性。氯原纤维在体内转化为4-氯苯氧基异丁酸(CPIB)和4-羟基-N-二甲基丁酰胺(HMB)[1]。

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氯贝胺名称

[ CAS 号 ]:
26717-47-5

[ 中文名 ]:
氯贝胺

[ 英文名 ]:
clofibride

[英文别名 ]:

Clofibride
Clofibrida [INN-Spanish]
MG 46
EINECS 247-912-7
Lipenan
Clofibridum [INN-Latin]

氯贝胺生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体内研究]

氯原纤维(口服,400；500和1000 mg/kg；单次)可快速且大量地再吸收并水解为4-氯苯氧基异丁酸(CPIB)和4-羟基-N-二甲基丁胺(HMB)[1]。动物模型：雄性CD大鼠、雄性和雌性比格犬、橄榄狒狒猴[1]剂量：4001000 mg/kg(大鼠)；500 mg/kg(狗和猴子)给药：口服,单次结果：HMB快速代谢,大鼠血清中主要活性代谢物CPIB的半衰期约为12小时,狗为43±9小时,狒狒为6±1小时。

氯贝胺物理化学性质

[ 密度 ]:
1.163g/cm3

[ 沸点 ]:
448.7ºC at 760mmHg

[ 分子式 ]:
C₁₆H₂₂ClNO₄

[ 分子量 ]:
327.80300

[ 闪点 ]:
225.2ºC

[ 精确质量 ]:
327.12400

[ PSA ]:
55.84000

[ LogP ]:
2.90900

[ 蒸汽压 ]:
3.04E-08mmHg at 25°C

[ 折射率 ]:
1.515

氯贝胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE9458000

CHEMICAL NAME :: Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ester with 4-hydroxy-N,N-dimethylbutyramide

CAS REGISTRY NUMBER :: 26717-47-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H22-Cl-N-O4

MOLECULAR WEIGHT :: 327.84

WISWESSER LINE NOTATION :: GR DOX1&1&VO3VN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2485 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1175 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 14 gm/kg

SEX/DURATION :: male 7 day(s) pre-mating female 7 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

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氯贝胺安全信息

[ 海关编码 ]:
2924299090

氯贝胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

氯贝胺