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盐酸美贝维林

盐酸美贝维林用途

Mebeverine hydrochloride 是β-苯乙胺的衍生物，能够抑制α1 repector的活性，为消化道的一种解痉药。

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盐酸美贝维林名称

[ CAS 号 ]:
2753-45-9

[ 中文名 ]:
盐酸麦皮凡林

[ 英文名 ]:
Mebeverine hydrochloride

[中文别名 ]:

[英文别名 ]:

MFCD00867721
MebeverineHydrochloride
Mebeverine hydrochloride
EINECS 220-400-0
Mebeverine (hydrochloride)

盐酸美贝维林物理化学性质

[ 沸点 ]:
543.8ºC at 760mmHg

[ 熔点 ]:
105-107ºC

[ 分子式 ]:
C₂₅H₃₆ClNO₅

[ 分子量 ]:
466.01000

[ 闪点 ]:
282.7ºC

[ 精确质量 ]:
465.22800

[ PSA ]:
57.23000

[ LogP ]:
5.40450

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
6.92E-12mmHg at 25°C

[ 储存条件 ]:
2-8°C

盐酸美贝维林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YX5425000

CHEMICAL NAME :: Veratric acid, 4-(ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl ester, hydrochloride

CAS REGISTRY NUMBER :: 2753-45-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C25-H35-N-O5.Cl-H

MOLECULAR WEIGHT :: 466.07

WISWESSER LINE NOTATION :: 1OR BO1 DVO4N2&Y1&1R DO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2821584

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2821584

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,338,1972

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盐酸美贝维林安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YX5425000

盐酸美贝维林文献

Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.

Pak. J. Pharm. Sci. 26(1) , 175-83, (2013)

This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetr...

Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.

Pharm. Dev. Technol. 16(4) , 331-42, (2011)

Mebeverine HCl is a water soluble drug commonly used to treat irritable bowel syndrome by acting directly on the smooth muscles of the colon. This work was aimed at the formulation and in vitro evalua...

Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.

J. Pharm. Biomed. Anal. 54(4) , 646-52, (2011)

An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines wh...

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