9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine

[ 分子式 ]:
C₂₂H₃₀ClN₆O₆PS₂

[ 分子量 ]:
605.06700

[ 精确质量 ]:
604.10900

[ PSA ]:
229.17000

[ LogP ]:
3.73800

详细MSDS(安全技术说明书)

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor.

Eur. J. Pharmacol. 269 , 265-268, (1994)

In the present study, the inhibitory effect of the cGMP analog (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate ((Rp)-8-pCPT-cGMPS) on the cGMP-dependent protein kinase-mediat...

Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel.

J. Neurosci. 16 , 1389-1399, (1996)

Nitric oxide (NO) and carbon monoxide (CO) have been identified as two diffusible signaling messengers in the brain, capable of stimulating soluble guanylate cyclase. Locus coeruleus (LC) is rich in t...

The nitric oxide/cGMP pathway couples muscarinic receptors to the activation of Ca2+ influx.

J. Neurosci. 16 , 1702-1709, (1996)

Inward currents activated by 8-bromc-cGMP and by muscarinic agonist were compared in N1E-115 mouse neuroblastoma cells using perforated-patch voltage clamp and Fura-2 imaging. The cGMP analog activate...

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