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尼可莫尔

尼可莫尔用途

尼可莫是一种口服活性降血脂剂,可提高高密度脂蛋白胆固醇(HDL-C)水平。尼可莫抑制血浆游离脂肪酸的快速升高[1][2]。
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尼可莫尔名称

[ CAS 号 ]:
27959-26-8

[ 中文名 ]:
尼可莫尔

[ 英文名 ]:
Nicomol

[中文别名 ]:

[英文别名 ]:

尼可莫尔生物活性

[ 描述 ]:

尼可莫是一种口服活性降血脂剂,可提高高密度脂蛋白胆固醇(HDL-C)水平。尼可莫抑制血浆游离脂肪酸的快速升高[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 其他 >> 其他

[参考文献]

[1]. N Yamazaki, et al. Arrhythmogenic effects of acute free fatty acid mobilization on ischemic heart. Recent Adv Stud Cardiac Struct Metab. 1976 May 26-29;12:271-7.

[2]. S Ikeda, et al. Effect of nicomol on high density lipoprotein (HDL) subfractions, HDL2e and HDL3e, separated by electrophoresis. Acta Med Okayama. 1981 Apr;35(2):143-8.

尼可莫尔物理化学性质

[ 密度 ]:
1.316g/cm3

[ 沸点 ]:
763.3ºC at 760mmHg

[ 分子式 ]:
C34H32N4O9

[ 分子量 ]:
640.64

[ 闪点 ]:
415.4ºC

[ 精确质量 ]:
640.21700

[ PSA ]:
176.99000

[ LogP ]:
3.51200

[ 蒸汽压 ]:
1.71E-24mmHg at 25°C

[ 折射率 ]:
1.596

尼可莫尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT2065000
CHEMICAL NAME :
Nicotinic acid, 1,1,3,3-tetraester with 2-hydroxy-1,1,3,3-cyclohexanetetramethanol
CAS REGISTRY NUMBER :
27959-26-8
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C34-H32-N4-O9
MOLECULAR WEIGHT :
640.70
WISWESSER LINE NOTATION :
T6NJ CVO1- AL6TJ BQ A1OV- CT6NJ& C1OV- CT6NJ& C1OV- CT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977
TYPE OF TEST :
LD20 - Lethal Dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14(5),741,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,237,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>17800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,237,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>14700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,237,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,237,1968 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
168 gm/kg
SEX/DURATION :
male 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,755,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
42 gm/kg
SEX/DURATION :
female 35 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,755,1977
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尼可莫尔安全信息

[ 海关编码 ]:
2933399090

尼可莫尔海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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