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N-去甲盐酸多塞平

N-去甲盐酸多塞平用途

盐酸诺多西平是多塞平的主要代谢产物。多塞平是一种三环类抗抑郁药,广泛用于治疗轻度抑郁症[1]。

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N-去甲盐酸多塞平名称

[ CAS 号 ]:
2887-91-4

[ 中文名 ]:
去甲多塞平盐酸盐

[ 英文名 ]:
nordoxepin

[中文别名 ]:

[英文别名 ]:

nordoxepin
N-DesMethyldoxepin-d3 Hydrochloride
NorDoxepinHydrochloride
demethyldoxepin
3-(Dibenz[b,e]oxepin-11(6H)-ylidene)-N-Methyl
N-Desmethyldoxepin
N-DesMethyldoxepin Hydrochloride

N-去甲盐酸多塞平生物活性

[ 描述 ]:

盐酸诺多西平是多塞平的主要代谢产物。多塞平是一种三环类抗抑郁药,广泛用于治疗轻度抑郁症[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Negrusz A, et al. Detection of doxepin and its major metabolite desmethyldoxepin in hair following drug therapy. J Anal Toxicol. 1998;22(6):531-536.

N-去甲盐酸多塞平物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
420.8±44.0 °C at 760 mmHg

[ 熔点 ]:
159-160ºC

[ 分子式 ]:
C₁₈H₂₀ClNO

[ 分子量 ]:
265.350

[ 闪点 ]:
174.5±17.9 °C

[ 精确质量 ]:
265.146667

[ PSA ]:
21.26000

[ LogP ]:
4.59

[ 外观性状 ]:
powder | white to off-white

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
-20°C Freezer

N-去甲盐酸多塞平MSDS

详细MSDS(安全技术说明书)

N-去甲盐酸多塞平安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
22-50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ WGK德国 ]:
3

N-去甲盐酸多塞平文献

Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(27) , 3025-30, (2009)

Perhexiline is a drug that is used for treatment of moderate to severe angina pectoris that has not responded to other treatment. It has a low therapeutic index, and saturable metabolism that is also ...

Simultaneous determination of doxepin and nordoxepin in serum using high-performance liquid chromatography.

J. Chromatogr. A. 419 , 445-51, (1987)

Quantitative determination of E- and Z-doxepin and E- and Z-desmethyldoxepin by high-performance liquid chromatography.

Ther. Drug Monit. 17(4) , 371-6, (1995)

A high-performance liquid chromatographic (HPLC) method was developed for the quantitative, simultaneous determination of the following four compounds in serum: E-doxepin, Z-doxepin, E-desmethyldoxepi...

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