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黄曲霉毒醇Ⅰ

黄曲霉毒醇Ⅰ用途

实验用致癌物。

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黄曲霉毒醇Ⅰ名称

[ CAS 号 ]:
29611-03-8

[ 中文名 ]:
黄曲霉毒醇Ⅰ

[ 英文名 ]:
Aflatoxicol

[英文别名 ]:

ETHYL 4-(4-ISOPROPYLPHENYL)-4-OXOBUTYRATE
aflatoxicol A

黄曲霉毒醇Ⅰ生物活性

[ 描述 ]:

Aflatoxin (Aflatoxin R0) 是 aflatoxin B1 的代谢物,由 Rhizopus spp 产生,为一种诱变致癌性真菌毒素。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Nakazato M, et al. Interconversion of aflatoxin B1 and aflatoxicol by several fungi. Appl Environ Microbiol. 1990 May;56(5):1465-70.

[2]. Carvajal M, et al. Aflatoxin B1 and its interconverting metabolite aflatoxicol in milk: the situation in Mexico. Food Addit Contam. 2003 Nov;20(11):1077-86.

黄曲霉毒醇Ⅰ物理化学性质

[ 密度 ]:
1.56g/cm3

[ 沸点 ]:
552.1ºC at 760mmHg

[ 分子式 ]:
C₁₇H₁₄O₆

[ 分子量 ]:
314.28900

[ 闪点 ]:
210.2ºC

[ 精确质量 ]:
314.07900

[ PSA ]:
78.13000

[ LogP ]:
2.12720

[ 蒸汽压 ]:
5.02E-13mmHg at 25°C

[ 折射率 ]:
1.698

黄曲霉毒醇Ⅰ毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY1934000

CAS REGISTRY NUMBER :: 29611-03-8

LAST UPDATED :: 199410

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C17-H14-O6

MOLECULAR WEIGHT :: 314.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 gm/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - testicular tumors

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 20 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,79,1986