10H-Phenothiazine-10-carboxylicacid, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
名称
[ CAS 号 ]:
298-51-1
[ 英文名 ]:
10H-Phenothiazine-10-carboxylicacid, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
[英文别名 ]:
- Phenolphthalidin
物理化学性质
[ 沸点 ]:
469.3ºC at 760 mmHg
[ 分子式 ]:
C19H23ClN2O2S
[ 分子量 ]:
378.91600
[ 闪点 ]:
237.6ºC
[ 精确质量 ]:
378.11700
[ PSA ]:
58.08000
[ LogP ]:
5.63470
[ 蒸汽压 ]:
5.57E-09mmHg at 25°C
[ 折射率 ]:
1.612
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SN7350000
- CHEMICAL NAME :
- Phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride
- CAS REGISTRY NUMBER :
- 298-51-1
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C19-H22-N2-O2-S.Cl-H
- MOLECULAR WEIGHT :
- 378.95
- WISWESSER LINE NOTATION :
- T C666 BN ISJ BVO2N2&2 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 13,59,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 13,59,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 620 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 13,59,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 26 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 90,241,1952
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