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链甾醇

链甾醇用途

地甾醇是一种类似于胆固醇的分子。桥甾醇是胆固醇生物合成布洛赫途径中胆固醇的直接前体。地甾醇,作为一种内源性代谢产物,用于研究胆固醇代谢[1]。

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链甾醇名称

[ CAS 号 ]:
313-04-2

[ 中文名 ]:
链甾醇

[ 英文名 ]:
Desmesterol

[中文别名 ]:

3Β-羟基-5,24-胆甾二烯

[英文别名 ]:

cholest-5,24-dien-3β-ol
Desmosterol
Cholesta-5,24-dien-3b-ol
Desmesterol
Cholesta-5,24-dien-3-β-ol
3b-Cholesta-5,24-dien-3-ol
EINECS 206-236-2
Cholesta-5,24-dien-3-ol, (3β)-
MFCD00056432
3ß-hydroxy-5,24-cholestadiene

链甾醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Clark RM, et al. Desmosterol in human milk. Lipids. 1983;18(3):264-266.

链甾醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
483.2±14.0 °C at 760 mmHg

[ 熔点 ]:
121.5ºC

[ 分子式 ]:
C₂₇H₄₄O

[ 分子量 ]:
384.638

[ 闪点 ]:
209.2±12.4 °C

[ 精确质量 ]:
384.339203

[ PSA ]:
20.23000

[ LogP ]:
9.54

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
-20°C

链甾醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

链甾醇合成路线

详细合成路线

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链甾醇文献

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids.

J. Chromatogr. A. 1371 , 184-95, (2014)

Recently, hydroxy sterols and bile acids have gained growing interest as they are important regulators of energy homoeostasis and inflammation. The high number of different hydroxy sterols and bile ac...

Sterol Composition in Infant Formulas and Estimated Intake.

J. Agric. Food Chem. 63 , 7245-51, (2015)

Sterol contents in infant formulas (IFs) from the European market were determined, and their intakes by infants between 0 and 6 months were evaluated. Total animal sterols (mg/100 mL) ranged from 1.71...

Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.

Hum. Mol. Genet. 24 , 2808-25, (2015)

NSDHL is a 3β-hydroxysterol dehydrogenase that is involved in the removal of two C-4 methyl groups in one of the later steps of cholesterol biosynthesis. Mutations in the gene encoding the enzyme are ...

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链甾醇