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BETA-六六六

BETA-六六六用途

气相色谱分析标准。有机合成。

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BETA-六六六名称

[ CAS 号 ]:
319-85-7

[ 中文名 ]:
β-六六六

[ 英文名 ]:
β-Hexachlorocyclohexane

[中文别名 ]:

[英文别名 ]:

Hexachlorocyclohexane-β
beta-hexachlorocyclohexane
ENT 9,233
EINECS 200-659-6
b-BHC
b-Hexachlorocyclohexane
1-α,2-β,3-α,4-β,5-α,6-β-Hexachlorocyclohexane
b-Hexachlorobenzene
β-BHC
β-lindane

BETA-六六六物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
288.0±0.0 °C at 760 mmHg

[ 熔点 ]:
≥300ºC

[ 分子式 ]:
C₆H₆Cl₆

[ 分子量 ]:
290.830

[ 闪点 ]:
157.5±23.9 °C

[ 精确质量 ]:
287.860077

[ LogP ]:
3.99

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
通风低温干燥

BETA-六六六MSDS

BETA-六六六毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GV4375000

CHEMICAL NAME :: Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-isomer

CAS REGISTRY NUMBER :: 319-85-7

BEILSTEIN REFERENCE NO. :: 1907338

LAST UPDATED :: 199710

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C6-H6-Cl6

MOLECULAR WEIGHT :: 290.82

WISWESSER LINE NOTATION :: L6TJ AG BG CG DG EG FG BETA

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ALLVAR Alimentation et la Vie. (Societe Scientifique d'Hygiene Alimentaire, 16, rue de l'Estrapade, 75005 Paris, France) V.39- 1951- Volume(issue)/page/year: 43,-,1955

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,273,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 672 mg/kg/2W-C

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 41,531,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22750 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,697,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8736 mg/kg/26W-C

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Related to Chronic Data - death

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 100,59,1950

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1989 mg/kg/30D-C

TOXIC EFFECTS :: Peripheral Nerve and Sensation - recording from peripheral motor nerve

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 27,704,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg/30D-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in other cell count (unspecified) Immunological Including Allergic - decrease in cellular immune response

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,293,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 2250 mg/kg/90D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 70,85P,1974 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,433,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 672 mg/kg/

SEX/DURATION :: male 2 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 41,531,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,195,1979 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 0.5 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg/m3;Skin JAN 1993

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BETA-六六六安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336-H412

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P210-P273-P280-P304 + P340 + P312-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,T,N

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25-50/53-40-25-21

[ 安全声明 (欧洲) ]:
S7;S16;S45;S60;S61;S36/S37

[ 危险品运输编码 ]:
UN1230 3/PG 2

[ RTECS号 ]:
GV4375000

BETA-六六六合成路线

BETA-六六六上下游产品

BETA-六六六上游产品

BETA-六六六下游产品

BETA-六六六文献

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Environ. Int. 59 , 485-93, (2013)

Legacy organochlorine contaminants were determined in adipose tissues from 294 polar bears (Ursus maritimus) sampled in East Greenland in 23 of the 28years between 1983 and 2010. Of 19 major legacy co...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Arch. Toxicol. 89 , 2413-27, (2015)

Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicatin...

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