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盐酸美法仑

盐酸美法仑名称

[ CAS 号 ]:
3223-07-2

[ 中文名 ]:
左旋苯丙氨酸氮芥盐酸盐

[ 英文名 ]:
Melphalan hydrochloride

[中文别名 ]:

[英文别名 ]:

盐酸美法仑物理化学性质

[ 沸点 ]:
473.1ºC at 760mmHg

[ 分子式 ]:
C₁₃H₁₉Cl₃N₂O₂

[ 分子量 ]:
341.661

[ 闪点 ]:
239.9ºC

[ 精确质量 ]:
340.051208

[ PSA ]:
66.56000

[ LogP ]:
3.42730

[ 外观性状 ]:
固体

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

盐酸美法仑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY4025000

CHEMICAL NAME :: Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride, L-

CAS REGISTRY NUMBER :: 3223-07-2

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H18-Cl2-N2-O2.Cl-H

MOLECULAR WEIGHT :: 341.69

WISWESSER LINE NOTATION :: QVYZ1R DN2G2G &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1200 ug/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 57,369,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 430 ug/kg

TOXIC EFFECTS :: Blood - leukopenia Blood - thrombocytopenia Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 430 ug/kg

TOXIC EFFECTS :: Blood - leukopenia Blood - agranulocytosis Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 ug/kg/4W

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 36,915,1966

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盐酸美法仑安全信息

[ 危害码 (欧洲) ]:
Xn

[ 海关编码 ]:
2922499990

盐酸美法仑海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%