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1-胡椒基哌嗪

1-胡椒基哌嗪名称

[ CAS 号 ]:
32231-06-4

[ 中文名 ]:
1-胡椒基哌嗪

[ 英文名 ]:
Methylenedioxybenzylpiperazine

[中文别名 ]:

[英文别名 ]:

1-(1,3-Benzodioxol-5-yl-methyl)piperazine
1-piperonylpiperazine
1-(3,4-Methylenedioxybenzyl)piperazine
EINECS 250-968-5
1-[(3,4-methylenedioxyphenyl)methyl]piperazine
Piperazine,1-(3,4-methylenedioxybenzyl)
1-Benzo[1,3]dioxol-5-ylmethyl-piperazine
4-(3,4-methylenedioxybenzyl)piperazine
5-(piperazinylmethyl)-2H-benzo[d]1,3-dioxolene
1-(1,3-Benzodioxol-5-ylmethyl)piperazine

1-胡椒基哌嗪物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
330.5±0.0 °C at 760 mmHg

[ 熔点 ]:
36-40 °C(lit.)

[ 分子式 ]:
C₁₂H₁₆N₂O₂

[ 分子量 ]:
220.268

[ 闪点 ]:
158.4±26.5 °C

[ 精确质量 ]:
220.121185

[ PSA ]:
33.73000

[ LogP ]:
1.22

[ 外观性状 ]:
白色至黄色或黄色-褐色结晶固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.577

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：微溶；可溶于：乙醇,甲醇

1-胡椒基哌嗪MSDS

1-胡椒基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM1550000

CHEMICAL NAME :: Piperazine, 1-(3,4-methylenedioxybenzyl)-

CAS REGISTRY NUMBER :: 32231-06-4

BEILSTEIN REFERENCE NO. :: 0885038

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H16-N2-O2

MOLECULAR WEIGHT :: 220.30

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1- DT6M DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,555,1974

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1-胡椒基哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
3259

[ WGK德国 ]:
3

[ RTECS号 ]:
TM1550000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2934999090

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1-胡椒基哌嗪海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-胡椒基哌嗪文献

Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain.

Brain Res. 590(1-2) , 341-4, (1992)

The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperaz...

A novel caffeic acid-1-piperonylpiperazine hybridization compound HBU-47 inhibits LPS-mediated inflammation in RAW264.7 macrophage cells.

Int. Immunopharmacol. 19(1) , 60-5, (2014)

In the present study, we synthesized a new hybrid compound by coupling caffeic acid and 1-piperonylpiperazine. The synthetic compound, acetyl-caffeic acid-1-piperonylpiperazine (HBU-47), showed potent...

Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine.

Eur. J. Pharmacol. 228(2-3) , 171-4, (1992)

The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurot...

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