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5-甲基-2-硫脲啶

5-甲基-2-硫脲啶用途

5-甲基-2-硫尿苷(2-硫-5-甲基尿苷)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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5-甲基-2-硫脲啶名称

[ CAS 号 ]:
32738-09-3

[ 中文名 ]:
5-甲基-2-硫脲啶

[ 英文名 ]:
5-methyl-2-thiouridine

[英文别名 ]:

2-Sulfamyl-4-methyl-phenyl-thioharnstoff
5-Methyl-2-thio-uridin
5-methyl-2-thioureido-benzenesulfonamide
4-Methyl-2-sulphamylphenylthiourea

5-甲基-2-硫脲啶生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

5-甲基-2-硫脲啶物理化学性质

[ 密度 ]:
1.63g/cm3

[ 熔点 ]:
216-219 °C

[ 分子式 ]:
C₁₀H₁₄N₂O₅S

[ 分子量 ]:
274.29

[ 精确质量 ]:
274.06200

[ PSA ]:
140.06000

[ 折射率 ]:
1.703

[ 储存条件 ]:
-20°C，密封，干燥

5-甲基-2-硫脲啶MSDS

详细MSDS(安全技术说明书)

5-甲基-2-硫脲啶安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

5-甲基-2-硫脲啶上下游产品

5-甲基-2-硫脲啶上游产品

5-甲基-2-硫脲啶下游产品

5-甲基-2-硫脲啶海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-甲基-2-硫脲啶文献

Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon.

Proc. Natl. Acad. Sci. U. S. A. 82 , 4905-4909, (1985)

Proton NMR analyses have been made to elucidate the conformational characteristics of modified nucleotides as found in the first position of the anticodon of tRNA [derivatives of 5-methyl-2-thiouridin...

CD spectra of 5-methyl-2-thiouridine in tRNA-Met-f from an extreme thermophile.

Nucleic Acids Res. 3 , 1703-1713, (1976)

5-Methyl-2-thiouridine (S) in tRNA-Met-f from an extreme thermophile is located in the TpsiC region, replacing T, and has a positive CD band centered at 310 nm. Upon heating, the profiles of the chang...

Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.

Nucleic Acids Res. 33 , 5297-5307, (2005)

Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4'-thio RNA. The phosphorothioates are excellent mimi...

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