Lorazepam glucuronide

[ 密度 ]:
1.76g/cm3

[ 沸点 ]:
779.5ºC at 760mmHg

[ 分子式 ]:
C₂₁H₁₈Cl₂N₂O₈

[ 分子量 ]:
497.28200

[ 闪点 ]:
425.2ºC

[ 精确质量 ]:
496.04400

[ PSA ]:
157.91000

[ LogP ]:
0.59140

[ 折射率 ]:
1.731

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 1648 3 / PGII

Commentary on: Dou C, Bournique J, Zinda M, Gnezda M, Nally A, Salamone S. Comparison of rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and temazepam-glucuronide catalyzed by E. coli beta-glucuronidase using the on-line benzodiazepine screening immunoassay on the Roche/Hitachi 917 analyzer.

J. Forensic Sci. 47(2) , 427-8, (2002)

Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration.

Am. J. Kidney Dis. 45(2) , 360-71, (2005)

The objective is to study the population pharmacokinetics of lorazepam and midazolam in critically ill patients with acute renal failure who are treated with continuous venovenous hemofiltration (CVVH...

Biotransformation and excretion of lorazepam in patients with chronic renal failure.

Br. J. Clin. Pharmacol. 3(6) , 1033-9, (1976)

To evaluate the effect of end-stage renal insufficiency and haemodialysis on the elimination of lorazepam, single oral doses of the drug (2.5 mg) were administered to normal subjects and patients with...

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