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高乌甲素

高乌甲素用途

高乌甲素 (Lappaconitine) 是从高乌头中分离到的一种天然产物,具有镇痛作用。

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高乌甲素名称

[ CAS 号 ]:
32854-75-4

[ 中文名 ]:
高乌甲素

[ 英文名 ]:
Lappaconitine

[中文别名 ]:

[英文别名 ]:

LAPPACONITINE
acetyl-10-deoxysepaconitine
N-Acetylpuberanidine
lappaconintine
Aconitum kusnezoffii Reichb

高乌甲素生物活性

[ 描述 ]:

高乌甲素 (Lappaconitine) 是从高乌头中分离到的一种天然产物,具有镇痛作用。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> P2X受体

天然产物 >> 生物碱

研究领域 >> 其他

[参考文献]

[1]. Guo X, et al.Effects of central Ca2+ on analgesic action of lappaconitine. Zhongguo Yao Li Xue Bao. 1989 Nov;10(6):504-7.

[2]. Ono M, et al. Pharmacological studies of lappaconitine: supraspinal-spinal interaction in antinociception. Archives Internationales de Pharmacodynamie et de Therapie [1991, 309:32-41]

[3]. Heubach JF, et al. Cardiac effects of lappaconitine and N-deacetyllappaconitine, two diterpenoid alkaloids from plants of the Aconitum and Delphinium species. Planta Med. 1998 Feb;64(1):22-6.

[相关活性小分子]

三磷酸腺苷二钠 | 1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪 | A-740003 | A 438079 | AF-353 | AZD9056盐酸盐 | PSB-12062 | A-317491 | A-804598 | 一个839977 | Gefapixant | GW791343(盐酸盐) | CE-224535 | JNJ-54175446

高乌甲素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
720.7±60.0 °C at 760 mmHg

[ 熔点 ]:
217-218ºC

[ 分子式 ]:
C₃₂H₄₄N₂O₈

[ 分子量 ]:
584.700

[ 闪点 ]:
389.7±32.9 °C

[ 精确质量 ]:
584.309753

[ PSA ]:
126.79000

[ LogP ]:
2.13

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
2-8C

高乌甲素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR5569552

CHEMICAL NAME :: Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate), (1-alpha,14-alpha,16-beta)-

CAS REGISTRY NUMBER :: 32854-75-4

BEILSTEIN REFERENCE NO. :: 0072755

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C32-H44-N2-O8

MOLECULAR WEIGHT :: 584.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,301,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 7,337,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,301,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 7,337,1951

高乌甲素

高乌甲素用途

高乌甲素名称

高乌甲素生物活性

高乌甲素物理化学性质

高乌甲素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

高乌甲素合成路线

详细合成路线

高乌甲素上下游产品

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