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KH7

KH7用途

KH7 是一种可溶性腺苷酸环化酶 (sAC) 的特异性抑制剂,其在细胞中测得对重组sACt 蛋白 (人源和其它) 的 IC50 值为 3-10 μM。

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KH7名称

[ CAS 号 ]:
330676-02-3

[ 中文名 ]:
KH7

[ 英文名 ]:
KH 7

[英文别名 ]:

MNI-caged-L-glutamate
KH7

KH7生物活性

[ 描述 ]:

KH7 是一种可溶性腺苷酸环化酶 (sAC) 的特异性抑制剂,其在细胞中测得对重组sACt 蛋白 (人源和其它) 的 IC50 值为 3-10 μM。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

IC50: 3-10 μM (recombinant sACt)[1].

[参考文献]

[1]. Hess KC, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005 Aug;9(2):249-59.

KH7物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 分子式 ]:
C₁₇H₁₅BrN₄O₂S

[ 分子量 ]:
419.296

[ 精确质量 ]:
418.009888

[ PSA ]:
115.67000

[ LogP ]:
6.01

[ 折射率 ]:
1.716

[ 储存条件 ]:
2-8℃

KH7MSDS

详细MSDS(安全技术说明书)

KH7安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

KH7文献

Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.

J. Immunol. 194 , 5472-87, (2015)

PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucin...

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.

J. Exp. Med. 212 , 1021-41, (2015)

CD99 is a critical regulator of leukocyte transendothelial migration (TEM). How CD99 signals during this process remains unknown. We show that during TEM, endothelial cell (EC) CD99 activates protein ...

Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.

Am. J. Physiol. Gastrointest. Liver Physiol. 309 , G703-15, (2015)

Inappropriate activation of pattern recognition receptors has been described as a potential trigger in the development of inflammatory bowel disease (IBD). In this study, we evaluated the activity and...

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KH7