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5-氟-2-甲基苯甲酸

5-氟-2-甲基苯甲酸用途

【用途一】
用作医药中间体

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5-氟-2-甲基苯甲酸名称

[ CAS 号 ]:
33184-16-6

[ 中文名 ]:
5-氟-2-甲基苯甲酸

[ 英文名 ]:
5-Fluoro-2-methylbenzoic acid

[中文别名 ]:

[英文别名 ]:

3-Fluoro-6-methylbenzoic acid
5-Fluoro-2-methylbenzoic acid
QVR CF F1
5-Fluoro-2-methyl-benzoic acid
5-Fluor-2-methyl-benzoesaeure
Benzoic acid,5-fluoro-2-methyl
MFCD00042294
Benzoic acid, 5-fluoro-2-methyl-
2-methyl-5-fluorobenzoic acid
5-Fluoro-o-toluic acid

5-氟-2-甲基苯甲酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
262.1±20.0 °C at 760 mmHg

[ 熔点 ]:
130-132 °C(lit.)

[ 分子式 ]:
C₈H₇FO₂

[ 分子量 ]:
154.138

[ 闪点 ]:
112.3±21.8 °C

[ 精确质量 ]:
154.043015

[ PSA ]:
37.30000

[ LogP ]:
2.62

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
室温

5-氟-2-甲基苯甲酸MSDS

5-氟-2-甲基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2916399090

5-氟-2-甲基苯甲酸合成路线

5-氟-2-甲基苯甲酸上下游产品

5-氟-2-甲基苯甲酸上游产品

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5-氟-2-甲基苯甲酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

5-氟-2-甲基苯甲酸文献

Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor. Gillmore AT, et al.

Org. Process Res. Dev. 16(12) , 2063-72, (1999)

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.

Bioorg. Med. Chem. 19 , 4935, (2011)

HIV-1 integrase (IN) is a validated therapeutic target for antiviral drug design. However, the emergence of viral strains resistant to clinically studied IN inhibitors demands the discovery of novel i...

Structure-activity relationship of HIV-1 protease inhibitors containing alpha-hydroxy-beta-amino acids. Detailed study of P1 site.

Bioorg. Med. Chem. 7(9) , 2063-72, (1999)

The structure-activity relationship of HIV-1 protease (HIV-1 PR) inhibitors containing alpha-hydroxy-beta-amino acids is discussed. We demonstrated that substituent groups on the P1 aromatic rings of ...

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