环丙喹宗
环丙喹宗用途
Ciproquazone 具有镇痛活性,可用于治疗脊柱炎。
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环丙喹宗名称
[ CAS 号 ]:
33453-23-5
[ 中文名 ]:
环丙喹宗
[ 英文名 ]:
Ciproquazone
[英文别名 ]:
- Ciproquazonum [INN-Latin]
- CIPROQUAZONE
- SL-573
- Ciproquazona
- Ciproquazona [INN-Spanish]
环丙喹宗生物活性
[ 描述 ]:
Ciproquazone 具有镇痛活性,可用于治疗脊柱炎。
[参考文献]
1. Vega S, et al. Thiophene isosteres: synthesis and biological evaluation of 3-substituted derivatives of 4-phenyl-2-thioxo-benzo [4, 5] thieno [2, 3-d] pyrimidine. European journal of medicinal chemistry, 1991, 26(3): 323-329.
环丙喹宗物理化学性质
[ 密度 ]:
1.26g/cm3
[ 沸点 ]:
483.8ºC at 760mmHg
[ 分子式 ]:
C19H18N2O2
[ 分子量 ]:
306.35800
[ 闪点 ]:
246.4ºC
[ 精确质量 ]:
306.13700
[ PSA ]:
44.12000
[ LogP ]:
3.48210
[ 折射率 ]:
1.653
环丙喹宗毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA3100333
- CHEMICAL NAME :
- 2(1H)-Quinazolinone, 1-(cyclopropylmethyl)-6-methoxy-4-phenyl-
- CAS REGISTRY NUMBER :
- 33453-23-5
- BEILSTEIN REFERENCE NO. :
- 0761592
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H18-N2-O2
- MOLECULAR WEIGHT :
- 306.39
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg/30D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in testicular weight
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9100 mg/kg/13W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979
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