4-Desacetylvinblastine

4-Desacetylvinblastine is a a pro-drug of Vinblastine. An anti-tumor agent used in the treatment of prostate cancer.

[ 熔点 ]:
189-191℃

[ 分子式 ]:
C₄₄H₅₆N₄O₈

[ 分子量 ]:
768.93700

[ 精确质量 ]:
768.41000

[ PSA ]:
148.03000

[ LogP ]:
3.36090

Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography.

Cancer Chemother. Pharmacol. 32(4) , 286-92, (1993)

We have developed and validated a selective analytical procedure, based on ion-exchange normal-phase liquid chromatography with fluorescence detection and liquid-liquid extraction, for the analysis of...

Disposition of the monoclonal antibody-vinca alkaloid conjugate KS1/4-DAVLB (LY256787) and free 4-desacetylvinblastine in tumor-bearing nude mice.

J. Pharmacol. Exp. Ther. 241(2) , 695-703, (1987)

The monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB (LY256787), and free 4-desacetylvinblastine (DAVLB) were administered i.v. to male athymic nude mice bearing P3/UCLA human lung adenocarci...

Quantitation of human anti-mouse antibody in serum by flow cytometry.

Cytometry 13(3) , 275-81, (1992)

Clinical investigations utilizing murine monoclonal antibodies require techniques for the detection of the human anti-mouse antibody (HAMA) response in patient serum. We report here a flow cytometric ...

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