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2-(3,4-环氧环己基)乙基三甲氧基硅烷

2-(3,4-环氧环己基)乙基三甲氧基硅烷用途

医药中间体

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2-(3,4-环氧环己基)乙基三甲氧基硅烷名称

[ CAS 号 ]:
3388-04-3

[ 中文名 ]:
三甲氧基[2-(7-氧杂二环[4.1.0]庚-3-基)乙基]硅烷

[ 英文名 ]:
2-(3,4 epoxycyclohexyl)ethyltrimethoxysilane

[中文别名 ]:

[英文别名 ]:

CE6250
EINECS 222-217-1
s530
2-(2,2,3,4,4,4-HEXAFLUOROBUTOXY)ETHANOL
MFCD00014485
2-(3,4-Epoxycyclohexyl)Ethyltrimethoxysilane
NUCA 186
Silane, [β-(3,4-epoxycyclohexyl)ethyl]trimethoxy-
y4086
KBM 303

2-(3,4-环氧环己基)乙基三甲氧基硅烷物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
263.5±13.0 °C at 760 mmHg

[ 熔点 ]:
<0ºC

[ 分子式 ]:
C₁₁H₂₂O₄Si

[ 分子量 ]:
246.376

[ 闪点 ]:
89.7±20.2 °C

[ 精确质量 ]:
246.128738

[ PSA ]:
40.22000

[ LogP ]:
1.28

[ 外观性状 ]:
液体;Colorless to Almost colorless clear liquid

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.454

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

2-(3,4-环氧环己基)乙基三甲氧基硅烷MSDS

详细MSDS(安全技术说明书)

2-(3,4-环氧环己基)乙基三甲氧基硅烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VV4000000

CHEMICAL NAME :: Silane, beta-(3,4-epoxycyclohexyl)ethyltrimethoxy-

CAS REGISTRY NUMBER :: 3388-04-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C11-H22-O4-Si

MOLECULAR WEIGHT :: 246.42

WISWESSER LINE NOTATION :: T36 BOTJ E2-SI-O1&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/17/1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year: 8,11,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year: 8,11,1974

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >290 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year: 8,11,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6300 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 2/11/1964 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1587 gm/kg/76W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,579,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9076 No. of Facilities: 367 (estimated) No. of Industries: 17 No. of Occupations: 23 No. of Employees: 15389 (estimated) No. of Female Employees: 3865 (estimated)

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2-(3,4-环氧环己基)乙基三甲氧基硅烷安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H350

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R45;R46

[ 安全声明 (欧洲) ]:
S53-S23-S36/37/39-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VV4000000

[ 海关编码 ]:
2932999099

2-(3,4-环氧环己基)乙基三甲氧基硅烷制备

（1）三乙氧基硅烷的合成将三氯硅烷、乙醇和溶剂苯加入搅拌反应釜，搅拌加热下进行反应。反应结束后进行蒸馏，蒸出溶剂并回收循环使用，剩下的产物冷却后出料即得成品。

（2）γ-氨基丙基三乙氧基硅烷的合成
① 由三乙氧基硅烷与丙烯胺进行加成反应制得，但是，丙烯胺的毒性很大。

② 氯丙基三乙氧基硅烷与氨或胺反应而制得。

γ-氨丙基三乙氧基硅烷可由以下三种方法制得：一种是氯丙基三乙氧基硅烷胺化法（参见A-1160硅烷偶联剂）；另一种是丙烯与三乙氧基氢硅的反应；还有一种即通过γ氨丙三乙氧基硅烷的还原反应。在生产中还可使用如下工艺方法。
（1）三乙氧基氢硅的制备　三乙氧基氢硅的合成工艺较为成熟，有三氯氢硅的乙酯化和硅粉法合成HSI(OEt)3两条路线可供选择。前一种方法的反应式如下：

（2）丙烯胺的制备　通常采用氯丙烯胺化法，其反应是在一定的压力下进行，产品收率为50%。反应式如下：

KH-550的制备　由丙烯胺与三氧基氢硅反应而得：

通过催化剂的选择可使KH-550的收率有明显提高。为了提高反应速度，缩短反应时间，丙烯胺采用滴加法。其滴加速度以控制体系温度为100～400℃为依据，该温度下丙烯胺的蒸气量较大。为了减小回流量，提高丙烯胺的瞬间转化率，反应设备的造型与设计至关重要。

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2-(3,4-环氧环己基)乙基三甲氧基硅烷海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(3,4-环氧环己基)乙基三甲氧基硅烷文献

[Preparation and evaluation of alkyl ether-bonded phase for reversed-phase high performance liquid chromatography].

Se Pu 19(6) , 485-8, (2001)

A new silane coupling agent, beta-(3,4-epoxycyclohexyl)ethyltrimethoxy silane, was for the firsty time used to react with octanol, then the intermediate product was coupled onto porous silica to obtai...

Evaluation of the developmental toxicity of beta-(3,4-epoxycyclohexyl)ethyltrimethoxysilane in Fischer 344 rats and New Zealand white rabbits.

Fundam. Appl. Toxicol. 10(3) , 439-52, (1988)

beta-(3,4-epoxycyclohexyl)ethyltrimethoxysilane (ECEMS, CAS No. 3388-04-3) is mutagenic in vitro and weakly carcinogenic in mice after dermal application. Timed pregnant Fischer 344 rats and New Zeala...

Design and application of high-sensitivity two-photon initiators for three-dimensional microfabrication.

J. Photochem. Photobiol. A: Chem. 158(2) , 163-170, (2003)

更多文献

2-(3,4-环氧环己基)乙基三甲氧基硅烷

2-(3,4-环氧环己基)乙基三甲氧基硅烷用途

2-(3,4-环氧环己基)乙基三甲氧基硅烷名称

2-(3,4-环氧环己基)乙基三甲氧基硅烷物理化学性质

2-(3,4-环氧环己基)乙基三甲氧基硅烷MSDS

详细MSDS(安全技术说明书)

2-(3,4-环氧环己基)乙基三甲氧基硅烷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

2-(3,4-环氧环己基)乙基三甲氧基硅烷安全信息

2-(3,4-环氧环己基)乙基三甲氧基硅烷制备

2-(3,4-环氧环己基)乙基三甲氧基硅烷海关

2-(3,4-环氧环己基)乙基三甲氧基硅烷文献

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