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(4S,5R)-4-羟基-5-(羟甲基)二氢呋喃-2(3H)-酮

名称

[ CAS 号 ]:
34371-14-7

[ 中文名 ]:
D-(+)-核糖酸-gamma-内酯

[ 英文名 ]:
(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one

[英文别名 ]:

2-deoxy-D-erythro-pentono-1,5-lactone
(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-one
2-deoxy-D-ribonolactone
2-Deoxy-ribono-1,4-lactone
Deoxyribonolactone
2-Deoxyribonolactone
2-Deoxy-D-ribono-1,4-lactone
2-Deoxy-D-ribonic-1,4-lactone

物理化学性质

[ 密度 ]:
1.438g/cm3

[ 沸点 ]:
395.3ºC at 760mmHg

[ 分子式 ]:
C₅H₈O₄

[ 分子量 ]:
132.11500

[ 闪点 ]:
179.1ºC

[ 精确质量 ]:
132.04200

[ PSA ]:
66.76000

[ 折射率 ]:
1.521

[ 储存条件 ]:
2-8°C

MSDS

安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932209090

合成路线

海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.

Mutat. Res. Fundam. Mol. Mech. Mutagen. 762 , 32-9, (2014)

A signature of ionizing radiation is the induction of DNA clustered damaged sites. Non-double strand break (DSB) clustered damage has been shown to compromise the base excision repair pathway, extendi...

Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links.

Meth. Enzymol. 408 , 48-64, (2006)

DNA base lesions arising from oxidation or alkylation are processed primarily by the base excision repair pathway (BER). The damaged bases are excised by DNA N-glycosylases, which generate apurinic/ap...

Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone.

J. Am. Chem. Soc. 134(19) , 8090-3, (2012)

Oxidized abasic sites such as 2-deoxyribonolactone (L) are produced in DNA by a variety of oxidizing agents, including potent cytotoxic antitumor natural products. 2-Deoxyribonolactone is labile under...

更多文献

(4S,5R)-4-羟基-5-(羟甲基)二氢呋喃-2(3H)-酮

名称

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

海关

文献

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