泊利噻嗪
泊利噻嗪用途
聚噻嗪是一种有效的口服噻嗪利尿剂,具有抗高血压作用。聚噻嗪可减轻水肿,降低血压。聚噻嗪还具有光毒性[1][2][3]。
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泊利噻嗪名称
[ CAS 号 ]:
346-18-9
[ 中文名 ]:
泊利噻嗪
[ 英文名 ]:
polythiazide (200 mg)
[英文别名 ]:
- Polythiazide
- Polythiazidum
- Politiazida
- Nephril
- P-2525
- Renese
- Drenusil
泊利噻嗪生物活性
[ 描述 ]:
聚噻嗪是一种有效的口服噻嗪利尿剂,具有抗高血压作用。聚噻嗪可减轻水肿,降低血压。聚噻嗪还具有光毒性[1][2][3]。
[ 相关类别 ]:
[体外研究]
在蓝光2000装置(Ex:325nm)下,聚噻嗪(500μM,1分钟)诱导显著的光毒性NHIK 3025细胞死亡[2]。
[体内研究]
聚噻嗪(口服灌胃,10 mg/kg,每日5天)增加了胆固醇喂养的C57BL/cdJ小鼠的血浆胆固醇水平[3]。多噻嗪(口服给药,0.4 mg/k g)对高血压狗和大鼠具有利尿和排尿作用[1]。动物模型:胆固醇喂养的C57BL/cdJ小鼠[3]剂量:10mg/kg给药:口服灌胃,每天5天结果:导致血浆总胆固醇水平上升约13%,非高密度脂蛋白分数增加。动物模型:高血压犬[1]剂量:0.4mg/kg给药:口服给药,每日5天结果:钠和氯的排泄增加。动物模型:高血压大鼠[1]剂量:0.05、0.1、0.2、0.4mg/kg给药:口服,每日两次,共3天。结果:显示利钠和利尿作用。
[参考文献]
泊利噻嗪物理化学性质
[ 密度 ]:
1.598g/cm3
[ 沸点 ]:
580.1ºC at 760mmHg
[ 熔点 ]:
202.5°
[ 分子式 ]:
C11H13ClF3N3O4S3
[ 分子量 ]:
439.88200
[ 闪点 ]:
304.7ºC
[ 精确质量 ]:
438.97100
[ PSA ]:
151.63000
[ LogP ]:
4.59280
[ 折射率 ]:
1.566
泊利噻嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK9275000
- CHEMICAL NAME :
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl- 3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 346-18-9
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C11-H13-Cl-F3-N3-O4-S3
- MOLECULAR WEIGHT :
- 439.90
- WISWESSER LINE NOTATION :
- T66 BSWN EM DHJ C1 D1S1XFFF HG ISZW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 300 ug/kg/5D-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 70,1163,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,793,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969
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相关化合物
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