甲氧炔雌醇
甲氧炔雌醇名称
[ CAS 号 ]:
34816-55-2
[ 中文名 ]:
甲氧炔雌醇
[ 英文名 ]:
Moxestrol
[英文别名 ]:
- 11beta-Methoxyethinylestradiol
- Moxestrolum
- Moxestrol
- RU 2858
甲氧炔雌醇物理化学性质
[ 密度 ]:
1.221g/cm3
[ 沸点 ]:
477.715ºC at 760 mmHg
[ 分子式 ]:
C21H26O3
[ 分子量 ]:
326.42900
[ 闪点 ]:
242.714ºC
[ 精确质量 ]:
326.18800
[ PSA ]:
49.69000
[ LogP ]:
3.23750
[ 折射率 ]:
1.609
甲氧炔雌醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RC8945000
- CHEMICAL NAME :
- 19-Nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-di ol, 11-beta-methoxy-
- CAS REGISTRY NUMBER :
- 34816-55-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C21-H26-O3
- MOLECULAR WEIGHT :
- 326.47
- WISWESSER LINE NOTATION :
- L E5 B666TTT&J CO1 E1 FQ F1UU1 OQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 400 mg/kg/39W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 50 ug/kg
- SEX/DURATION :
- female 16-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Newborn - delayed effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 250 ug/kg
- SEX/DURATION :
- female 16-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1250 ug/kg
- SEX/DURATION :
- female 16-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - live birth index (measured after birth)
MUTATION DATA
- TEST SYSTEM :
- Rodent - hamster
- DOSE/DURATION :
- 160 mg/kg/20W (Continuous)
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 311,191,1994
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