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2-亚氨基-1-咪唑啉乙酸

2-亚氨基-1-咪唑啉乙酸用途

环肌酸是一种肌酸类似物,通过提供高水平的ATP作为一种有效的生物能量保护剂。环肌酸穿过膜,进入大脑,可被肌酸激酶磷酸化和去磷酸化[1]。

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2-亚氨基-1-咪唑啉乙酸名称

[ CAS 号 ]:
35404-50-3

[ 中文名 ]:
2-亚氨基-1-咪唑烷乙酸

[ 英文名 ]:
(2-Iminoimidazolidin-1-yl)acetic acid

[中文别名 ]:

2-亚氨基-1-咪唑啉乙酸

[英文别名 ]:

2-(2-amino-4,5-dihydroimidazol-1-yl)acetic acid
MFCD00134455
(2-Iminoimidazolidin-1-yl)acetic acid
(2-Amino-4,5-dihydro-1H-imidazol-1-yl)acetic acid
1H-Imidazole-1-acetic acid, 2-amino-4,5-dihydro-

2-亚氨基-1-咪唑啉乙酸生物活性

[ 描述 ]:

环肌酸是一种肌酸类似物,通过提供高水平的ATP作为一种有效的生物能量保护剂。环肌酸穿过膜,进入大脑,可被肌酸激酶磷酸化和去磷酸化[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Salwa A Elgebaly, et al. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion. Expert Rev Cardiovasc Ther. 2019 Sep;17(9):683-697.

[2]. Tyler K Ulland, et al. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 2017 Aug 10;170(4):649-663.e13.

2-亚氨基-1-咪唑啉乙酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
278.4±42.0 °C at 760 mmHg

[ 熔点 ]:
25-28 °C(lit.)

[ 分子式 ]:
C₅H₉N₃O₂

[ 分子量 ]:
143.144

[ 闪点 ]:
122.2±27.9 °C

[ 精确质量 ]:
143.069473

[ PSA ]:
76.42000

[ LogP ]:
-1.99

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.660

[ 储存条件 ]:
-20°C Freezer

2-亚氨基-1-咪唑啉乙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

2-亚氨基-1-咪唑啉乙酸上下游产品

2-亚氨基-1-咪唑啉乙酸上游产品

2-亚氨基-1-咪唑啉乙酸下游产品

2-亚氨基-1-咪唑啉乙酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-亚氨基-1-咪唑啉乙酸文献

Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.

J. Neurosci. 35(14) , 5707-23, (2015)

The distribution of mitochondria within mature, differentiated neurons is clearly adapted to their regional physiological needs and can be perturbed under various pathological conditions, but the func...

Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).

Neurochem. Res. 39(10) , 1988-96, (2014)

The γ-aminobutyric acid (GABA) transporters (GATs) are key membrane transporter proteins involved in the termination of GABAergic signaling at synapses in the mammalian brain and proposed drug targets...

Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase.

Int. J. Cancer 78(1) , 46-52, (1998)

Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine), an analog of creatine and a substrate for creatine kinase (EC 2.7.3.2), inhibits the stimulated motility of tumor cells which possess creatine kin...

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