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9-氨基-6-氯-2-甲氧基吖啶

9-氨基-6-氯-2-甲氧基吖啶用途

9-氨基-6-氯-2-甲氧基吖啶是一种pH敏感的荧光探针。9-氨基-6-氯-2-甲氧基吖啶经常用于测量特定底物通过假定的H+/溶质反转运系统穿过液泡膜时液泡pH值的变化[1]。

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9-氨基-6-氯-2-甲氧基吖啶名称

[ CAS 号 ]:
3548-09-2

[ 中文名 ]:
9-氨基-6-氯-2-甲氧基吖啶

[ 英文名 ]:
9-AMINO-6-CHLORO-2-METHOXYACRIDINE

[英文别名 ]:

MFCD00083236
6-chloro-2-methoxyacridin-9-amine

9-氨基-6-氯-2-甲氧基吖啶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Carqueijeiro I, et al. Analytical and Fluorimetric Methods for the Characterization of the Transmembrane Transport of Specialized Metabolites in Plants. Methods Mol Biol. 2016;1405:121-135.

9-氨基-6-氯-2-甲氧基吖啶物理化学性质

[ 密度 ]:
1.367g/cm3

[ 沸点 ]:
475.1ºC at 760mmHg

[ 分子式 ]:
C₁₄H₁₁ClN₂O

[ 分子量 ]:
258.70300

[ 闪点 ]:
241.2ºC

[ 精确质量 ]:
258.05600

[ PSA ]:
48.14000

[ LogP ]:
4.21340

[ 折射率 ]:
1.734

[ 储存条件 ]:
-20°C

9-氨基-6-氯-2-甲氧基吖啶MSDS

9-氨基-6-氯-2-甲氧基吖啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7330000

CHEMICAL NAME :: Acridine, 9-amino-3-chloro-7-methoxy-

CAS REGISTRY NUMBER :: 3548-09-2

BEILSTEIN REFERENCE NO. :: 0226315

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H11-Cl-N2-O

MOLECULAR WEIGHT :: 258.72

WISWESSER LINE NOTATION :: T C666 BNJ EG IZ LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 28,1,1947

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9-氨基-6-氯-2-甲氧基吖啶安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H351

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
22-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
AR7330000

[ 海关编码 ]:
2933990090

9-氨基-6-氯-2-甲氧基吖啶合成路线

9-氨基-6-氯-2-甲氧基吖啶上下游产品

9-氨基-6-氯-2-甲氧基吖啶上游产品

9-氨基-6-氯-2-甲氧基吖啶下游产品

9-氨基-6-氯-2-甲氧基吖啶海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

9-氨基-6-氯-2-甲氧基吖啶文献

Vma9p need not be associated with the yeast V-ATPase for fully-coupled proton pumping activity in vitro.

Biochemistry 54(3) , 853-8, (2015)

Vacuolar-type ATPases (V-ATPases) acidify numerous intracellular compartments in all eukaryotic cells and are responsible for extracellular acidification in some specialized cells. V-ATPases are large...

Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4.

Am. J. Physiol. Renal Physiol. 309 , F120-36, (2015)

We previously reported that the deletion of the pH sensor GPR4 causes a non-gap metabolic acidosis and defective net acid excretion (NAE) in the GPR4 knockout mouse (GPR4-/-) (Sun X, Yang LV, Tiegs BC...

Copper transport and compartmentation in grape cells.

Plant Cell Physiol. 53(11) , 1866-80, (2012)

Copper-based fungicides have been widely used against several grapevine (Vitis vinifera L.) diseases since the late 1800s when the Bordeaux mixture was developed, but their intensive use has raised ph...

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