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甲磺酸2-氯乙酯

甲磺酸2-氯乙酯名称

[ CAS 号 ]:
3570-58-9

[ 中文名 ]:
甲磺酸2-氯乙酯

[ 英文名 ]:
Ethanol, 2-chloro-,1-methanesulfonate

[中文别名 ]:

2-氯乙基甲基磺酸

[英文别名 ]:

2-Chloroethylmethanesulfonate
2-Chloroethyl Methanesulfonate
2-Chloroethyl methanesulphonate
Methanesulfonic acid,2-chloroethyl ester
2-chloroethyl mesylate
2-Chlorethylmesylat
EINECS 222-672-6
CB 1506
Chloroethyl methanesulfonate
2-Chloroethylmethanesulfonate,puriss

甲磺酸2-氯乙酯物理化学性质

[ 密度 ]:
1.39 g/mL at 25ºC(lit.)

[ 沸点 ]:
125-126ºC9 mm Hg(lit.)

[ 熔点 ]:
6ºC

[ 分子式 ]:
C₃H₇ClO₃S

[ 分子量 ]:
158.60400

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
157.98000

[ PSA ]:
51.75000

[ LogP ]:
1.28220

[ 外观性状 ]:
液体;Colorless to Almost colorless clear liquid

[ 折射率 ]:
n20/D 1.456(lit.)

[ 储存条件 ]:
库房低温通风干燥

甲磺酸2-氯乙酯MSDS

甲磺酸2-氯乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK1960000

CHEMICAL NAME :: Ethanol, 2-chloro-, methanesulfonate

CAS REGISTRY NUMBER :: 3570-58-9

BEILSTEIN REFERENCE NO. :: 1754022

LAST UPDATED :: 199612

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C3-H7-Cl-O3-S

MOLECULAR WEIGHT :: 158.61

WISWESSER LINE NOTATION :: WS1&O2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 127 mg/kg

TOXIC EFFECTS :: Behavioral - coma Liver - other changes Tumorigenic - tumors at site of application

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 25 mg/kg

SEX/DURATION :: male 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Mold - Neurospora crassa

DOSE/DURATION :: 100 mmol/L

REFERENCE :: MGBUA3 Microbial Genetics Bulletin. (Ohio State Univ., College of Biological Science, Dept. of Microbiology, 484 W. 12th Ave., Columbus, OH 43210) No.1- 1950- Volume(issue)/page/year: 17,5,1960

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甲磺酸2-氯乙酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332-H351

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S23;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 2810 6

[ WGK德国 ]:
3

[ RTECS号 ]:
KK1960000

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甲磺酸2-氯乙酯文献

Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells.

Mutat. Res. 331(2) , 213-24, (1995)

The 2-chloroethyl methanesulfonate (2ClEMS)-induced alcohol dehydrogenase (Adh) null germline mutation frequency in treated Drosophila melanogaster second instar larval gonia was two orders of magnitu...

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