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4- 雌-3Alpha,17Β-二醇

4- 雌-3Alpha,17Β-二醇名称

[ CAS 号 ]:
35950-87-9

[ 中文名 ]:
4- 雌-3Alpha,17Β-二醇

[ 英文名 ]:
estren

[英文别名 ]:

ethylis oleas
ETHYLOLEATE,NF
ETHYL OLEATE,BP
Oleic acid ethyl
cis-ethyl oleate
MFCD00271605
OLEIC ACID ETHYL ESTER
Ethyloleat
oleic
Esterol 123

4- 雌-3Alpha,17Β-二醇物理化学性质

[ 分子式 ]:
C₁₈H₂₈O₂

[ 分子量 ]:
276.41400

[ 精确质量 ]:
276.20900

[ PSA ]:
40.46000

[ LogP ]:
3.28090

4- 雌-3Alpha,17Β-二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

4- 雌-3Alpha,17Β-二醇合成路线

详细合成路线

4- 雌-3Alpha,17Β-二醇上下游产品

4- 雌-3Alpha,17Β-二醇上游产品

4- 雌-3Alpha,17Β-二醇下游产品

4- 雌-3Alpha,17Β-二醇文献

Reversal of bone loss in mice by nongenotropic signaling of sex steroids.

Science 298 , 843-846, (2002)

We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actio...

The nongenotropic synthetic ligand 4-estren-3alpha17beta-diol is a high-affinity genotropic androgen receptor agonist.

Mol. Pharmacol. 67 , 744-748, (2005)

The nongenotropic ligand estren (Science 298:843-846, 2002) was evaluated for its transcriptional activity mediated by the human androgen receptor (AR). Our results show that estren can bind, transloc...

The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection.

Neurobiol. Dis. 19 , 331-339, (2005)

Estrogen has demonstrated neuroprotective properties, which may underlie the observed preventive effect of estrogen-based hormone therapy (HT) against the development of neurodegenerative disorders su...

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