氯甲苯噻嗪
氯甲苯噻嗪用途
氯甲苯噻嗪名称
[ CAS 号 ]:
364-98-7
[ 中文名 ]:
氯甲苯噻嗪
[ 英文名 ]:
diazoxide
[中文别名 ]:
[英文别名 ]:
- diazoxidum [INN_la]
- Hypertonalum
- Diazoxido
- Sodium dodecyl sulphate solution
- EINECS 206-668-1
- Mutabase
- Proglycem
- Dizoxide
- Diazossido
- MFCD00078578
氯甲苯噻嗪生物活性
[ 描述 ]:
[ 相关类别 ]:
[体外研究]
[体内研究]
[细胞实验]
[动物实验]
[参考文献]
[相关活性小分子]
氯甲苯噻嗪物理化学性质
[ 密度 ]:
1.6±0.1 g/cm3
[ 沸点 ]:
414.8±47.0 °C at 760 mmHg
[ 熔点 ]:
>310°C
[ 分子式 ]:
C8H7ClN2O2S
[ 分子量 ]:
230.671
[ 闪点 ]:
204.6±29.3 °C
[ 精确质量 ]:
229.991669
[ PSA ]:
66.91000
[ LogP ]:
1.08
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.692
[ 储存条件 ]:
Store at RT
[ 水溶解性 ]:
0.1 M NaOH: soluble
氯甲苯噻嗪MSDS
氯甲苯噻嗪毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK8185000
- CHEMICAL NAME :
- 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 364-98-7
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C8-H7-Cl-N2-O2-S
- MOLECULAR WEIGHT :
- 230.68
- WISWESSER LINE NOTATION :
- T66 BSWM ENJ D1 IG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 980 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 143,446,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 510 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 143,446,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 444 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 136,344,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 326 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 136,344,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 228 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 136,344,1962 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 65 mg/kg
- SEX/DURATION :
- female 110-114 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- JCNDBK Journal of Clinical Pharmacology and New Drugs. (Stamford, CT) V.11-13, 1971-73. For publisher information, see JCPCBR. Volume(issue)/page/year: 11,206,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7114 No. of Facilities: 63 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 612 (estimated) No. of Female Employees: 395 (estimated)
氯甲苯噻嗪安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22;R36/37/38
[ 安全声明 (欧洲) ]:
S22;S26;S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
DK8185000
[ 海关编码 ]:
2933990090
氯甲苯噻嗪合成路线
氯甲苯噻嗪上下游产品
氯甲苯噻嗪上游产品
氯甲苯噻嗪下游产品
氯甲苯噻嗪制备
由5-氯-2-乙酰胺基-N-乙酰基苯磺酰胺经高温环合而得。环合反应在250-260℃进行,搅拌15min。然后冷却,待物料凝固后研细,用乙醇洗涤,得二氮嗪粗品。用40倍量的80%乙醇重结晶,得成品。
氯甲苯噻嗪海关
[ 海关编码 ]: 2933990090
[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
氯甲苯噻嗪文献
Int. J. Clin. Exp. Pathol. 7(8) , 4755-64, (2014)
Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery and transplantation. The pathogenesis underlying IRI is complex, involving a series of s...
Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis.PLoS ONE 9(11) , e112529, (2014)
Loss of mitochondrial membrane potential (ΔΨm) is known to be closely linked to cell death by various insults. However, whether acceleration of the ΔΨm recovery process prevents cell necrosis remains ...
ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo.Invest. Ophthalmol. Vis. Sci. 54(7) , 4892-9, (2013)
To evaluate the expression of ATP-sensitive potassium (K(ATP)) channel subunits and study the effect of K(ATP) channel openers diazoxide and nicorandil on intraocular pressure (IOP) in an in vivo mous...
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区域:上海市普陀区
价格:
联系人:徐乾明
产品详情:二氮嗪
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Diazoxide
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥489.0/1g
¥519.0/100mg
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Diazoxide
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥163.0/250mg
¥465.0/1g
¥1738.0/5g
¥需询单/1ml
联系人:夏言
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥355.9/1g
¥124.9/250mg
¥375.9/1ml
¥1249.9/5g
联系人:阿拉丁
产品详情:二氮嗪
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相关化合物
【氯甲苯噻嗪】化源网提供氯甲苯噻嗪CAS号364-98-7,氯甲苯噻嗪MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氯甲苯噻嗪上化源网,专业又轻松。>>电脑版:氯甲苯噻嗪
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