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3-(4-氟苯甲酰)丙酸

3-(4-氟苯甲酰)丙酸用途

【用途一】
五氟利多、强心药咪苯嗪酮的中间体。

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3-(4-氟苯甲酰)丙酸名称

[ CAS 号 ]:
366-77-8

[ 中文名 ]:
3-(4-氟苯甲酰基)丙酸

[ 英文名 ]:
3-(4-Fluorobenzoyl)propionic acid

[中文别名 ]:

[英文别名 ]:

3-(4-Fluorobenzoyl)propionic Acid
Benzenebutanoic acid, 4-fluoro-γ-oxo-
β-(4-fluorobenzoyl)propionic acid
4-(4-Fluorophenyl)-4-oxobutanoic acid
MFCD00002793
Haloperidol metabolite III
EINECS 206-679-1

3-(4-氟苯甲酰)丙酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
374.4±22.0 °C at 760 mmHg

[ 熔点 ]:
100-102 °C(lit.)

[ 分子式 ]:
C₁₀H₉FO₃

[ 分子量 ]:
196.175

[ 闪点 ]:
180.3±22.3 °C

[ 精确质量 ]:
196.053574

[ PSA ]:
54.37000

[ LogP ]:
1.34

[ 外观性状 ]:
米色粒状的粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
室温，密封

3-(4-氟苯甲酰)丙酸MSDS

3-(4-氟苯甲酰)丙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;C: Corrosive;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S36/37/39-S26-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918300090

3-(4-氟苯甲酰)丙酸合成路线

3-(4-氟苯甲酰)丙酸制备

【方法一】
用氟苯与琥珀酸酐反应制得。

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3-(4-氟苯甲酰)丙酸海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

3-(4-氟苯甲酰)丙酸文献

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Psychopharmacology 205 , 21-33, (2009)

We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutan...

Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid.

J. Neurochem. 99(2) , 458-69, (2006)

Haloperidol, a dopamine D2 receptor blocker, is a classical neuroleptic drug that elicits extrapyramidal symptoms. Its metabolites include 3-(4-fluorobenzoyl) propionic acid (FBPA) and 4-(4-chlorophen...

Tissue distribution studies of [18F]haloperidol, [18F]-beta-(4-fluorobenzoyl)propionic acid, and [82Br]bromperidol by external scintigraphy.

J. Pharm. Sci. 70(9) , 985-9, (1981)

Tissue distribution studies of [18F]haloperidol and [82Br]bromperidol, two potent neuroleptic drugs, were performed in rats by serial sacrifice. The usefulness of external scintigraphy in obtaining ti...

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