MPP+ iodide

MPP+ iodide用途

MPP+ iodide 是神经毒素 MPTP 的一种有毒代谢物,通过选择性破坏黑质多巴胺能神经元,在动物模型中引起帕金森病症状。MPP+ iodide 被多巴胺转运体吸收进入多巴胺能神经元,通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。MPP+ iodide 也是 5-羟色胺转运体 (SERT) 的高亲和力底物。

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MPP+ iodide名称

[ CAS 号 ]:
36913-39-0

[ 中文名 ]:
N-甲基-4-苯基吡啶鎓碘化物

[ 英文名 ]:
MPP+ iodide

[英文别名 ]:

MFCD00055096

MPP+ iodide生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[体外研究]

MPP+(1-3 mM；24小时)显著降低细胞活力[1]。MPP+还抑制线粒体制剂中烟酰胺腺苷二核苷酸(NADH)连接呼吸的活性,并损害有氧糖酵解,因此目前认为NADH连接细胞呼吸的抑制可能构成MPP+神经毒性的最终分子机制[3]。细胞活力测定[1]细胞系：SH-SY5Y细胞浓度：1,2,3 mM孵育时间：24小时结果：用MPP+处理SH-SY5Y细胞,模拟PD时多巴胺能神经元丢失的过程；细胞活力呈剂量依赖性(1,2,3 mM孵育24小时)和时间依赖性(1 mM)。

[参考文献]

[1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.

[2]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45.

[3]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118.

MPP+ iodide物理化学性质

[ 分子式 ]:
C₁₁H₁₀IN

[ 分子量 ]:
283.10800

[ 精确质量 ]:
282.98600

[ PSA ]:
12.89000

[ LogP ]:
3.74680

[ 外观性状 ]:
粉末

[ 储存条件 ]:
室温，干燥，密封，避光

MPP+ iodideMSDS

详细MSDS(安全技术说明书)

MPP+ iodide安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
23/24/25-36/37/38

[ 安全声明 (欧洲) ]:
26-36-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ RTECS号 ]:
UU6580000

[ 海关编码 ]:
2933399090

MPP+ iodide上下游产品

MPP+ iodide上游产品

MPP+ iodide下游产品

MPP+ iodide海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

MPP+ iodide文献

A new dopaminergic nigro-olfactory projection.

Acta Neuropathol. 130 , 333-48, (2015)

Parkinson disease (PD) is a neurodegenerative disorder characterized by massive loss of midbrain dopaminergic neurons. Whereas onset of motor impairments reflects a rather advanced stage of the disord...

The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride-induced hepatocellular toxicity.

Drug Metab. Dispos. 42(7) , 1227-34, (2014)

Nitidine chloride (NC), a quaternary ammonium alkaloid, has numerous pharmacological effects, such as anticancer activity. However, it was found that NC also has hepatocellular toxicity. Because organ...

Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors.

Br. J. Pharmacol. 171(16) , 3868-80, (2014)

Inhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across t...

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