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3’:5’-环一磷酸-2’-O-一丁二酰腺苷

用途

2'-O-琥珀酰-cAMP是一种可以与乙酰胆碱酯酶共价偶联的cAMP类似物。2'-O-琥珀酰-cAMP结合物已被用作经典非均相竞争酶免疫分析中的示踪剂,允许测定cAMP[1][2]。

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名称

[ CAS 号 ]:
36940-87-1

[ 中文名 ]:
3’:5’-环一磷酸-2’-O-一丁二酰腺苷

[ 英文名 ]:
2'-O-Succinyl-cAMP

[英文别名 ]:

succinyladenosine 3',5'-cyclic monophosphate

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Pradelles P, et, al. Enzyme immunoassays of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate using acetylcholinesterase. Anal Chem. 1989 Mar 1;61(5):447-53.

[2]. Luttrell BM, et, al. Reaction coupling of chelation and antigen binding in the calcium ion-dependent antibody binding of cyclic AMP. J Biol Chem. 1991 Nov 15;266(32):21626-30.

物理化学性质

[ 密度 ]:
2.16g/cm3

[ 沸点 ]:
781.3ºC at 760mmHg

[ 分子式 ]:
C₁₄H₁₆N₅O₉P

[ 分子量 ]:
429.27900

[ 闪点 ]:
426.3ºC

[ 精确质量 ]:
429.06900

[ PSA ]:
208.02000

[ LogP ]:
0.17950

[ 折射率 ]:
1.849

[ 储存条件 ]:
-20 °C，密封，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.

Endocrinology 151 , 2151-2161, (2010)

In the adrenal cortex, the biosynthesis of steroid hormones is controlled by the pituitary-derived hormone ACTH. The functions of ACTH are principally relayed by activating cAMP-dependent signaling pa...

Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release

Neuroscience 164 , 1244-1251, (2009)

Histamine H3 autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca2+/CaMKII transduction pathways mediate ...

A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase.

Anal. Biochem. 402 , 129-136, (2010)

Nitric oxide (NO) mediates intercellular signaling through activation of its receptor, soluble guanylyl cyclase (sGC), leading to elevation of intracellular guanosine 3',5'-cyclic monophosphate (cGMP)...

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