甲羟苯丙胺

甲羟苯丙胺用途

Pholedrine is an Autonomic Agent. It is a a sympathomimetic vasoconstrictive drug.

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甲羟苯丙胺名称

[ CAS 号 ]:
370-14-9

[ 中文名 ]:
甲羟苯丙胺

[ 英文名 ]:
Pholedrine

[中文别名 ]:

[英文别名 ]:

4-[2-(methylamino)propyl]phenol

甲羟苯丙胺物理化学性质

[ 密度 ]:
1.014g/cm3

[ 沸点 ]:
279.4ºC at 760mmHg

[ 熔点 ]:
162-163°

[ 分子式 ]:
C₁₀H₁₅NO

[ 分子量 ]:
165.23200

[ 闪点 ]:
109ºC

[ 精确质量 ]:
165.11500

[ PSA ]:
32.26000

[ LogP ]:
1.93350

[ 折射率 ]:
1.532

[ 储存条件 ]:
−20°C

甲羟苯丙胺MSDS

甲羟苯丙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL8400000

CHEMICAL NAME :: Phenol, p-(2-(methylamino)propyl)-

CAS REGISTRY NUMBER :: 370-14-9

LAST UPDATED :: 199603

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H15-N-O

MOLECULAR WEIGHT :: 165.26

WISWESSER LINE NOTATION :: QR D1Y1&M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - changes in psychophysiological tests

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,442,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,101,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,328,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

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甲羟苯丙胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36-45-36/37-16-7

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SL8400000

[ 海关编码 ]:
2922299090

甲羟苯丙胺合成路线

甲羟苯丙胺上下游产品

甲羟苯丙胺上游产品

甲羟苯丙胺下游产品

甲羟苯丙胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

甲羟苯丙胺文献

Identification of new urinary metabolites of famprofazone in humans.

J. Anal. Toxicol. 22(1) , 55-60, (1998)

Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and ...

Urinary excretion of the main metabolites of methamphetamine, including p-hydroxymethamphetamine-sulfate and p-hydroxymethamphetamine-glucuronide, in humans and rats.

Xenobiotica 36(2-3) , 259-67, (2006)

The urinary concentrations of the main metabolites of methamphetamine (MA), specifically p-hydroxymethamphetamine-sulfate (p-OHMA-Sul) and p-hydroxymethamphetamine-glucuronide (p-OHMA-Glu), were direc...

LC-MS/MS analysis of pholedrine in a fatal intoxication case.

Forensic Sci. Int. 133(1-2) , 101-6, (2003)

Pholedrine (4'-hydroxymethamphetamine) is a cardiovascular agent exerting hypertensive and adrenergic effects. High doses may cause a drop in the peripheral circulation blood flow and increase blood p...

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