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双环己酮草酰二腙

双环己酮草酰二腙用途

铜试剂是一种螯合剂,用作铜分析试剂。铜嗪经常用于研究影响少突胶质细胞死亡和髓鞘丢失的因素[1][2]。

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双环己酮草酰二腙名称

[ CAS 号 ]:
370-81-0

[ 中文名 ]:
双环己酮草酰二腙

[ 英文名 ]:
oxalic bis(cyclohexylidenehydrazide)

[中文别名 ]:

[英文别名 ]:

Dicyclohexanoneoxaly dihydrazone
MFCD00001659
Bis(cyclohexanone) Oxalyldihydrazone
oxalic bis(cyclohexylidenehydrazide)
N,N'-bis(cyclohexylideneamino)oxamide
Oxalic acid bis(cyclohexylidenehydrazide)
Ethanedioic acid, bis(2-cyclohexylidenehydrazide)
N',N'-Dicyclohexylideneethanedihydrazide
Bis(cyclohexanone)oxalyldihydrazone
Cupferazone

双环己酮草酰二腙生物活性

[ 描述 ]:

铜试剂是一种螯合剂,用作铜分析试剂。铜嗪经常用于研究影响少突胶质细胞死亡和髓鞘丢失的因素[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体内研究]

铜(0.5 mg/100 mg饮食和水,即食；p.o.)在中枢神经系统中产生严重的海绵状状态,最显著的是在小鼠的脑干和小脑白质[1]。

[参考文献]

[1]. Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol. 1969 Feb;54(2):307-25.

[2]. Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33(1):27-37.

双环己酮草酰二腙物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
210-214 °C(lit.)

[ 分子式 ]:
C₁₄H₂₂N₄O₂

[ 分子量 ]:
278.350

[ 精确质量 ]:
278.174286

[ PSA ]:
82.92000

[ LogP ]:
0.85

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
1.626

[ 储存条件 ]:
2-8°C

双环己酮草酰二腙MSDS

双环己酮草酰二腙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RO2520000

CHEMICAL NAME :: Oxalic acid, bis(cyclohexylidenehydrazide)

CAS REGISTRY NUMBER :: 370-81-0

BEILSTEIN REFERENCE NO. :: 2388004

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H22-N4-O2

MOLECULAR WEIGHT :: 278.40

WISWESSER LINE NOTATION :: L6YTJ AUNMVVMNU- AL6YTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29400 mg/kg/7W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20160 mg/kg/8W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 24 gm/kg

SEX/DURATION :: female 3-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 gm/kg

SEX/DURATION :: female 3-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/14D (Continuous)

REFERENCE :: EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 47,313,1974

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双环己酮草酰二腙安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R21/22

[ 安全声明 (欧洲) ]:
S24/25-S2

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RO2520000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29280090

双环己酮草酰二腙合成路线

双环己酮草酰二腙上下游产品

双环己酮草酰二腙上游产品

双环己酮草酰二腙下游产品

双环己酮草酰二腙海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

双环己酮草酰二腙文献

Effect of high-dose 1.25 dihydroxyvitamin D3 on remyelination in the cuprizone model.

APMIS 122(12) , 1178-86, (2014)

Vitamin D supplementation is increasingly recommended to patients with multiple sclerosis (MS). To study the effect of high-dose vitamin D on remyelination, female C57Bl/6 mice were demyelinated with ...

Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans.

Behav. Brain Res. 287 , 265-75, (2015)

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Further to the symptoms resulting from demyelination, new studies point to the involvemen...

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.

Antioxid. Redox Signal. 22(9) , 772-84, (2015)

Several neurodegenerative disorders show alterations in glutamatergic synapses and increased susceptibility to excitotoxicity. Mounting evidence suggests a central role for the cellular prion protein ...

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