Phenothiazine, 10-(3-(beta-morpholinoethylamino)propyl)-2-trifluoromethyl-, dihydrochloride
名称
[ CAS 号 ]:
3772-70-1
[ 英文名 ]:
Phenothiazine, 10-(3-(beta-morpholinoethylamino)propyl)-2-trifluoromethyl-, dihydrochloride
物理化学性质
[ 密度 ]:
1.247g/cm3
[ 沸点 ]:
547.9ºC at 760 mmHg
[ 分子式 ]:
C22H27ClF3N3OS
[ 分子量 ]:
473.98200
[ 闪点 ]:
285.1ºC
[ 精确质量 ]:
473.15200
[ PSA ]:
53.04000
[ LogP ]:
5.81580
[ 折射率 ]:
1.565
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SP3325000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(beta-morpholinoethylamino)propyl)-2-trifluorom ethyl-, dihydrochloride
- CAS REGISTRY NUMBER :
- 3772-70-1
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C22-H26-F3-N3-O-S.2Cl-H
- MOLECULAR WEIGHT :
- 510.49
- WISWESSER LINE NOTATION :
- T C666 BN ISJ EXFFF B3N2&- AT6N DOTJ &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 616 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962
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相关化合物
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