4-(4-氯苯基)-4-羟基哌啶

4-(4-氯苯基)-4-羟基哌啶用途

由4-氯-α-甲基苯乙烯（[1712-70-5]）经环合，成盐、加成、水解而得。1.环合、成盐将4-氯-α-甲基苯乙烯加到氯化铵和甲醛混合液中，在60℃左右反应至反应液澄清。再加入甲醇，在45℃反应4h，蒸出甲醇，加入浓盐酸，在40-50℃下反应半小时，95-100℃下反应4h，放置过夜。加液碱至pH为10-11。用甲苯提取，减压回收甲苯，余液用丙酮稀释，加乙酸至pH为7，析出结晶，过滤，丙酮洗涤，干燥，得4-对氯苯1,2,3,6-四氢吡啶乙酸盐。2.加成、水解将上述乙酸盐溶解在冰醋酸中，在30℃以下通溴

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4-(4-氯苯基)-4-羟基哌啶名称

[ CAS 号 ]:
39512-49-7

[ 中文名 ]:
4-(4-氯苯基)-4-羟基哌啶

[ 英文名 ]:
4-(4-Chlorophenyl)-4-piperidinol

[中文别名 ]:

[英文别名 ]:

4-Piperidinol, 4-(4-chlorophenyl)-
4-(p-Chlorophenyl)-4-piperidinol
Haloperidol metabolite I
4-(4-Chlorophenyl)-4-piperidinol
4-(4-Chlorophenyl)piperidin-4-ol
4-Hydroxy-4-(p-chlorophenyl)piperidine
EINECS 254-479-8
4-(para-Chlorophenyl)-4-hydroxypiperidine
4-(p-Chlorophenyl)-4-hydroxypiperidine
MFCD00006001

4-(4-氯苯基)-4-羟基哌啶物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
344.5±42.0 °C at 760 mmHg

[ 熔点 ]:
137-140 °C(lit.)

[ 分子式 ]:
C₁₁H₁₄ClNO

[ 分子量 ]:
211.688

[ 闪点 ]:
162.1±27.9 °C

[ 精确质量 ]:
211.076385

[ PSA ]:
32.26000

[ LogP ]:
1.78

[ 外观性状 ]:
白色至奶油色-白色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.572

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
340 mg/L (20 ºC)

4-(4-氯苯基)-4-羟基哌啶MSDS

详细MSDS(安全技术说明书)

4-(4-氯苯基)-4-羟基哌啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29333999

4-(4-氯苯基)-4-羟基哌啶合成路线

详细合成路线

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4-(4-氯苯基)-4-羟基哌啶上游产品

4-(4-氯苯基)-4-羟基哌啶下游产品

4-(4-氯苯基)-4-羟基哌啶制备

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4-(4-氯苯基)-4-羟基哌啶海关

[ 海关编码 ]: 29333999

4-(4-氯苯基)-4-羟基哌啶文献

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Psychopharmacology 205 , 21-33, (2009)

We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutan...

In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.

Pharmacogenetics 8(5) , 383-9, (1998)

In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of r...

Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites.

J. Am. Soc. Mass Spectrom. 13(3) , 204-8, (2002)

Sonic spray ionization (SSI) was compared with atmospheric pressure chemical ionization (APCI) as an interface of high-performance liquid chromatography (HPLC)-mass spectrometry (MS) for sensitive ana...

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