3,4-脱氢-L-脯氨酸
3,4-脱氢-L-脯氨酸用途
3,4-脱氢-L-脯氨酸名称
[ CAS 号 ]:
4043-88-3
[ 中文名 ]:
3,4-脱氢-L-脯氨酸
[ 英文名 ]:
3,4-Dehydro-L-proline
[中文别名 ]:
[英文别名 ]:
- 3,4-Dehydro-L-proline
- (S)-2,5-Dihydro-1H-pyrrole-2-carboxylic acid
- (2S)-2,5-dihydro-1H-pyrrole-2-carboxylic acid
- EINECS 223-738-7
- MFCD00153487
3,4-脱氢-L-脯氨酸生物活性
3,4-脱氢-L-脯氨酸物理化学性质
[ 密度 ]:
1.252g/cm3
[ 沸点 ]:
279.3ºC at 760mmHg
[ 熔点 ]:
239-241ºC (dec.)
[ 分子式 ]:
C5H7NO2
[ 分子量 ]:
113.11
[ 闪点 ]:
122.7ºC
[ 精确质量 ]:
113.04800
[ PSA ]:
49.33000
[ 外观性状 ]:
固体;White to Amber to Dark green powder to crystal
[ 蒸汽压 ]:
0.00108mmHg at 25°C
[ 折射率 ]:
1.521
[ 储存条件 ]:
-15°C
[ 水溶解性 ]:
水溶性:可溶
3,4-脱氢-L-脯氨酸MSDS
3,4-脱氢-L-脯氨酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UX9371345
- CHEMICAL NAME :
- 1H-Pyrrole-2-carboxylic acid, 2,5-dihydro-, (S)-
- CAS REGISTRY NUMBER :
- 4043-88-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C5-H7-N-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 617 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,426,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 720 mg/kg/9D-I
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,127,1983
3,4-脱氢-L-脯氨酸安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 安全声明 (欧洲) ]:
S22-S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
UX9371345
[ 海关编码 ]:
2933990090
3,4-脱氢-L-脯氨酸合成路线
3,4-脱氢-L-脯氨酸上下游产品
3,4-脱氢-L-脯氨酸上游产品
3,4-脱氢-L-脯氨酸下游产品
3,4-脱氢-L-脯氨酸海关
[ 海关编码 ]: 2933990090
[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
3,4-脱氢-L-脯氨酸文献
Nat. Chem. Biol. 5 , 45-52, (2009)
Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...
Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.J. Biol. Chem. 279(53) , 55051-9, (2004)
Three human prolyl 4-hydroxylases (P4Hs) regulate the hypoxia-inducible transcription factors (HIFs) by hydroxylating a Leu-Xaa-Xaa-Leu-Ala-Pro motif. We report here that the two leucines in the Leu-G...
Overexpression of decorin by rat arterial smooth muscle cells enhances contraction of type I collagen in vitro.Arterioscler. Thromb. Vasc. Biol. 24(1) , 67-72, (2004)
Overexpression of decorin reduces neointimal thickening in balloon-injured carotid arteries of rats by decreasing the volume of neointimal extracellular matrix (ECM). We examined the hypothesis that d...
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相关化合物
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