2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

用途

7-(3-脱氧-β-D-红-内呋喃基)-7H-吡咯并[2,3-D]嘧啶-4-胺是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

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名称

[ CAS 号 ]:
40725-89-1

[ 英文名 ]:
2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

[英文别名 ]:

Tubercidin-5'-phosphat
tubercidin-5-monophosphate
3'-deoxytubercidin
TUBERCIDIN-5'-O-MONOPHOSPHATE SODIUM SALT
7-deaza-[5']adenylic acid
7-CH-5'-AMP SODIUM SALT
7-DEAZAADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT
5'-deoxy-5'-(methylthio)tubercidin
tubercidin 5'-phosphate

生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

[ 密度 ]:
1.75g/cm3

[ 沸点 ]:
601.3ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₄N₄O₃

[ 分子量 ]:
250.25

[ 闪点 ]:
317.5ºC

[ 精确质量 ]:
250.10700

[ PSA ]:
106.42000

[ LogP ]:
0.23540

[ 折射率 ]:
1.797

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8833100

CHEMICAL NAME :: 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 7-(3-deoxy-beta-D-erythro-pentofuranosyl)-

CAS REGISTRY NUMBER :: 40725-89-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H14-N4-O3

MOLECULAR WEIGHT :: 250.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 3200 ug/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,481,1987

点击显示

2-(5-amino-2,4,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolan-3-ol

用途

名称

生物活性

物理化学性质

毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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