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4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸

4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸用途

CTP抑制剂是一种高效、选择性的CTP抑制剂。CTP抑制剂抑制质膜柠檬酸转运蛋白(PMCT)[1]。

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4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸名称

[ CAS 号 ]:
412940-35-3

[ 中文名 ]:
4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸

[ 英文名 ]:
CTP Inhibitor

[英文别名 ]:

4-Chloro-3-(3-nitro-phenylsulfamoyl)-benzoic acid
CTP Inhibitor

4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸生物活性

[ 描述 ]:

CTP抑制剂是一种高效、选择性的CTP抑制剂。CTP抑制剂抑制质膜柠檬酸转运蛋白(PMCT)[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

CTP[1]

[参考文献]

[1]. Sun J, et al. Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis. Mol Cell Pharmacol. 2010; 2(3):101-110.

4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸物理化学性质

[ 分子式 ]:
C₁₃H₉ClN₂O₆S

[ 分子量 ]:
356.73800

[ 精确质量 ]:
355.98700

[ PSA ]:
137.67000

[ LogP ]:
4.42420

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸MSDS

详细MSDS(安全技术说明书)

4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

4-氯-3-[[(3-硝基苯基)氨基]磺酰基]-苯甲酸文献

Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis.

Mol. Cell. Pharmacol. 2(3) , 101-110, (2010)

Cytoplasmic citrate is the prime carbon source for fatty acid, triacylglycerol, and cholesterol biosyntheses, and also regulates glucose metabolism via its allosteric inhibition of phosphofructokinase...

Targeting mitochondrial citrate transport in breast cancer cell lines.

Anticancer Agents Med. Chem. 15(3) , 374-81, (2015)

Lipogenesis is considered to be a very important aspect of cancer metabolism and targeting de novo lipid synthesis or related pathways are among novel approaches to treat cancer. Many targets of the p...

Spatio-temporal dynamics of replication and transcription sites in the mammalian cell nucleus.

Chromosoma 117(6) , 553-67, (2008)

To study when and where active genes replicated in early S phase are transcribed, a series of pulse-chase experiments are performed to label replicating chromatin domains (RS) in early S phase and sub...

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