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2'-脱氧尿苷-5'-单磷酸二钠

2'-脱氧尿苷-5'-单磷酸二钠用途

2'-脱氧尿苷5'-单磷酸二钠通过双底物酶胸苷酸合酶(TS)还原甲基化为dTMP(2'-脱氧胸苷5'-单磷酸)。dTMP是DNA合成所需的核苷酸[1]。

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2'-脱氧尿苷-5'-单磷酸二钠名称

[ CAS 号 ]:
42155-08-8

[ 中文名 ]:
2-脱氧尿嘧啶核苷-5’-单磷酸二钠盐

[ 英文名 ]:
Disodium 2'-deoxy-5'-O-phosphonatouridine

[中文别名 ]:

[英文别名 ]:

5'-Uridylic acid, 2'-deoxy-, sodium salt (1:2)
2'-Deoxyuridine 5'-monophosphate disodium salt
EINECS 255-687-1
Disodium 2'-deoxy-5'-O-phosphonatouridine
MFCD00065282
2'-Deoxyuridine 5'-mono-phos-phate disodium salt

2'-脱氧尿苷-5'-单磷酸二钠生物活性

[ 描述 ]:

2'-脱氧尿苷5'-单磷酸二钠通过双底物酶胸苷酸合酶(TS)还原甲基化为dTMP(2'-脱氧胸苷5'-单磷酸)。dTMP是DNA合成所需的核苷酸[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28.

2'-脱氧尿苷-5'-单磷酸二钠物理化学性质

[ 密度 ]:
1.742 g/cm3

[ 分子式 ]:
C₉H₁₁N₂Na₂O₈P

[ 分子量 ]:
352.146

[ 精确质量 ]:
352.004852

[ PSA ]:
166.55000

[ 储存条件 ]:
−20°C

2'-脱氧尿苷-5'-单磷酸二钠MSDS

详细MSDS(安全技术说明书)

2'-脱氧尿苷-5'-单磷酸二钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36-37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

2'-脱氧尿苷-5'-单磷酸二钠文献

Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877 , 2937-2944, (2009)

To specifically quantify several metabolites of 5-fluorouracil (5-FU) and two endogenous monophosphate nucleotides, we developed an original method based on a liquid chromatography–tandem mass spectro...

Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX.

Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8924-9, (2013)

In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hydride dono...

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

J. Neurosci. 28 , 7219-7230, (2008)

Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie...

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