奥昔啡烷
奥昔啡烷名称
[ CAS 号 ]:
42281-59-4
[ 中文名 ]:
奥昔啡烷
[ 英文名 ]:
Oxilorphan
[英文别名 ]:
- (L)-BC-2605
- Oxilorfano [INN-Spanish]
- Levo-BC-2605
- Bristol laboratories BC 2605
- (-)-17-Cyclopropylmethylmorphinan-3,4-diol
- 3,14-dihydroxy-N-cyclopropylmethylmorphinan
- EINECS 255-749-8
奥昔啡烷物理化学性质
[ 密度 ]:
1.27g/cm3
[ 沸点 ]:
495.4ºC at 760mmHg
[ 分子式 ]:
C20H27NO2
[ 分子量 ]:
313.43400
[ 闪点 ]:
262.9ºC
[ 精确质量 ]:
313.20400
[ PSA ]:
43.70000
[ LogP ]:
2.91340
[ 折射率 ]:
1.653
奥昔啡烷毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QC7800000
- CHEMICAL NAME :
- Morphinan-3,14-diol, 17-(cyclopropylmethyl)-
- CAS REGISTRY NUMBER :
- 42281-59-4
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H27-N-O2
- MOLECULAR WEIGHT :
- 313.48
- WISWESSER LINE NOTATION :
- T6 G666/FQ 2AF Q FX ONT&TTJ AQ IQ O1- AL3TJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 14 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes
- REFERENCE :
- JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 16,183,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 26 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,746,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 315 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 193,23,1975
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