美替诺龙醋酸酯

美替诺龙醋酸酯用途

Metenolone醋酸盐是一种长效的蛋白同化激素，具有较低的雄激素特性。IC50 value:Target:Metenolone醋酸盐是一种天然存在的化合物，在驯养的怀孕猫科肾上腺腺体内发现。Metenolone醋酸盐用于口服给药。Methenolone醋酸盐可抑制下丘脑 - 垂体 - 性腺通路。[1] Methenolone醋酸盐作为口服制剂时，Methenolone不是17-α-烷基化，而是1-甲基化，便于提高口服生物利用度，且降低肝脏应力。[2]

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美替诺龙醋酸酯名称

[ CAS 号 ]:
434-05-9

[ 中文名 ]:
美替诺龙醋酸酯

[ 英文名 ]:
Methenolone Acetate

[中文别名 ]:

[英文别名 ]:

Primobolan
Methenolone acetate
Primonabol
EINECS 207-097-0
(5α)-1-Methyl-3-oxoandrost-1-en-17-yl acetate
Nibal
MFCD00864181
Methenolone (acetate)

美替诺龙醋酸酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
441.2±45.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₃₂O₃

[ 分子量 ]:
344.488

[ 闪点 ]:
189.9±28.8 °C

[ 精确质量 ]:
344.235138

[ PSA ]:
43.37000

[ LogP ]:
4.93

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
2~8℃

美替诺龙醋酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8408500

CHEMICAL NAME :: 5-alpha-Androst-1-en-3-one, 17-beta-hydroxy-1-methyl-, acetate

CAS REGISTRY NUMBER :: 434-05-9

LAST UPDATED :: 199309

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C22-H32-O3

MOLECULAR WEIGHT :: 344.54

WISWESSER LINE NOTATION :: L E5 B666 OV LUTJ A1 E1 FOV1 K1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 200 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,330,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 60 mg/kg

SEX/DURATION :: female 17-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: AVBIB9 Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967- Volume(issue)/page/year: 13,71,1974

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美替诺龙醋酸酯安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2942000000

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[ 海关编码 ]: 2942000000