5-羟基-D-色氨酸

5-羟基-D-色氨酸用途

D-5-羟基色氨酸(D-5-HTP)是5-HTP的D-异构体,可通过连续分离从DL-5-羟色氨酸中分离[1]。

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5-羟基-D-色氨酸名称

[ CAS 号 ]:
4350-07-6

[ 中文名 ]:
5-羟基-D-色氨酸

[ 英文名 ]:
(R)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID

[中文别名 ]:

[英文别名 ]:

Tryptophan,5-hydroxy-,D
C11H12N2O3
5-Hydroxytryptophan D-form
HRP
D-Tryptophan,5-hydroxy
D-5-Hydroxytryptophan

5-羟基-D-色氨酸生物活性

[ 描述 ]:

D-5-羟基色氨酸(D-5-HTP)是5-HTP的D-异构体,可通过连续分离从DL-5-羟色氨酸中分离[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. J Arendt, et al. Alternative pathways of 5-hydroxyindole metabolism. II. The role transamination in the metabolism of D-5-hydroxytryptophan in the rat. Biochem Pharmacol. 1967 Mar;16(3):419-22.

5-羟基-D-色氨酸物理化学性质

[ 熔点 ]:
27ºC

[ 分子式 ]:
C₁₁H₁₂N₂O₃

[ 分子量 ]:
220.22500

[ 精确质量 ]:
220.08500

[ PSA ]:
99.34000

[ LogP ]:
1.52820

5-羟基-D-色氨酸MSDS

详细MSDS(安全技术说明书)

5-羟基-D-色氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN7050000

CHEMICAL NAME :: Tryptophan, 5-hydroxy-, D-

CAS REGISTRY NUMBER :: 4350-07-6

LAST UPDATED :: 199109

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H12-N2-O3

MOLECULAR WEIGHT :: 220.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 69,523,1973

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5-羟基-D-色氨酸安全信息

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
20/21-20/21/22-36/37/38-65

[ 安全声明 (欧洲) ]:
26-36

[ 海关编码 ]:
2933990090

5-羟基-D-色氨酸合成路线

详细合成路线

5-羟基-D-色氨酸上下游产品

5-羟基-D-色氨酸上游产品

5-羟基-D-色氨酸下游产品

5-羟基-D-色氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%