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ZNAF-1F

ZNAF-1F用途

ZnAF-1F是一种有效的荧光团,其Kd值为2.2nm。ZnAF-1F可用作细胞中Zn2+的荧光探针。ZnAF-1F显示了489nm的λ激发和514nm的λ发射[1][2][3]。

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ZNAF-1F名称

[ CAS 号 ]:
443302-08-7

[ 中文名 ]:
ZNAF-1F

[ 英文名 ]:
ZnAF-1F

[英文别名 ]:

ZnAF-1F

ZNAF-1F生物活性

[ 描述 ]:

ZnAF-1F是一种有效的荧光团,其Kd值为2.2nm。ZnAF-1F可用作细胞中Zn2+的荧光探针。ZnAF-1F显示了489nm的λ激发和514nm的λ发射[1][2][3]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

ZnAF-1F(1µM)在100mM HEPES缓冲液中的Kon值为3.5*106 M-1s-1,Koff值为7.7*10-3 s-1[1]。ZnAF-1F是中性和微酸条件下的锌传感器[2]。

[参考文献]

[1]. Hirano T, et al. Improvement and biological applications of fluorescent probes for zinc, ZnAFs. J Am Chem Soc. 2002 Jun 12;124(23):6555-62.

[2]. Zhaohua Dai, et al. Tailoring tripodal ligands for zinc sensing. New J. Chem., 2007,31, 1708-1718.

[3]. Que EL, et al. Metals in neurobiology: probing their chemistry and biology with molecular imaging. Chem Rev. 2008 May;108(5):1517-49.

ZNAF-1F物理化学性质

[ 密度 ]:
1.49g/cm3

[ 沸点 ]:
822.1ºC at 760 mmHg

[ 分子式 ]:
C₃₄H₂₆F₂N₄O₅

[ 分子量 ]:
608.59100

[ 闪点 ]:
451ºC

[ 精确质量 ]:
608.18700

[ PSA ]:
128.79000

[ LogP ]:
6.22410

[ 折射率 ]:
1.715

ZNAF-1F安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

ZNAF-1F文献

Improvement and biological applications of fluorescent probes for zinc, ZnAFs.

J. Am. Chem. Soc. 124 , 6555-6562, (2002)

The development and cellular applications of novel fluorescent probes for Zn2+, ZnAF-1F, and ZnAF-2F are described. Fluorescein is used as a fluorophore of ZnAFs, because its excitation and emission w...

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