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Desmethylnortriptyline

Desmethylnortriptyline用途

Desmethylnortriptyline 是 Nortriptyline 的代谢产物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢产物,用于缓解抑郁症症状。

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Desmethylnortriptyline名称

[ CAS 号 ]:
4444-42-2

[ 英文名 ]:
Desmethylnortriptyline

[英文别名 ]:

Desmethylnortriptyline
N-desmethyl-nortriptyline
didesmethylamitriptyline

Desmethylnortriptyline生物活性

[ 描述 ]:

Desmethylnortriptyline 是 Nortriptyline 的代谢产物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢产物,用于缓解抑郁症症状。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Burch JE, et al. Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde. J Chromatogr. 1983 May 13;274:350-4.

[2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

Desmethylnortriptyline物理化学性质

[ 密度 ]:
1.127g/cm3

[ 沸点 ]:
399.2ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₁₉N

[ 分子量 ]:
249.35000

[ 闪点 ]:
191.8ºC

[ 精确质量 ]:
249.15200

[ PSA ]:
26.02000

[ LogP ]:
4.26600

[ 折射率 ]:
1.664

Desmethylnortriptyline安全信息

[ 海关编码 ]:
2921499090

Desmethylnortriptyline合成路线

详细合成路线

Desmethylnortriptyline上下游产品

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Desmethylnortriptyline下游产品

Desmethylnortriptyline海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%