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9β,11α-前列腺素F2

9β,11α-前列腺素F2用途

(5R)-地诺前列素是由花生四烯酸的环氧合酶代谢产生的代谢产物。(5R)-地诺前列素(前列腺素F2β)诱导含己糖粘蛋白的剂量依赖性释放[1][2]。

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9β,11α-前列腺素F2名称

[ CAS 号 ]:
4510-16-1

[ 中文名 ]:
同分异构体(物),同质异能素

[ 英文名 ]:
Prostaglandin F2β

[英文别名 ]:

9BETA, 11ALPHA-PROSTAGLANDIN F2
prostaglandin F2beta
Prostaglandin F2β

9β,11α-前列腺素F2生物活性

[ 描述 ]:

(5R)-地诺前列素是由花生四烯酸的环氧合酶代谢产生的代谢产物。(5R)-地诺前列素(前列腺素F2β)诱导含己糖粘蛋白的剂量依赖性释放[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Lamont JT, et, al. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Gastroenterology. 1983 Feb;84(2):306-13.

[2]. Jang Y, et, al. Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation. 2020 Jan 22;17(1):30.

9β,11α-前列腺素F2物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
531.0±50.0 °C at 760 mmHg

[ 熔点 ]:
105-106ºC

[ 分子式 ]:
C₂₀H₃₄O₅

[ 分子量 ]:
354.48

[ 闪点 ]:
289.0±26.6 °C

[ 精确质量 ]:
354.240631

[ PSA ]:
97.99000

[ LogP ]:
2.14

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.569

9β,11α-前列腺素F2毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ9658000

CHEMICAL NAME :: 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)- , stereoisomer

CAS REGISTRY NUMBER :: 4510-16-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H34-O5

MOLECULAR WEIGHT :: 354.54

WISWESSER LINE NOTATION :: L5TJ AQ B2U4VQ C1U1YQ5 DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10 mg/kg

SEX/DURATION :: female 19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 36,188P,1969