2,5-二甲基塞来考昔

2,5-二甲基塞来考昔用途

2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2. It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) and reduces prostaglandin E2 (PGE2) production in HeLa, A549, and HCA-7 cells. It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 μM. 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition.

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2,5-二甲基塞来考昔名称

[ CAS 号 ]:
457639-26-8

[ 中文名 ]:
2,5-二甲基塞来考昔

[ 英文名 ]:
2,5-DiMethyl Celecoxib

[英文别名 ]:

2,5-Dimethyl Celecoxib
2,5-Dimethyl-celecoxib

2,5-二甲基塞来考昔物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
516.7±60.0 °C at 760 mmHg

[ 分子式 ]:
C₁₈H₁₆F₃N₃O₂S

[ 分子量 ]:
395.399

[ 闪点 ]:
266.3±32.9 °C

[ 精确质量 ]:
395.091522

[ PSA ]:
86.36000

[ LogP ]:
4.67

[ 外观性状 ]:
white to beige

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
room temp

[ 水溶解性 ]:
DMSO: soluble20mg/mL, clear

2,5-二甲基塞来考昔MSDS

详细MSDS(安全技术说明书)

2,5-二甲基塞来考昔安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

2,5-二甲基塞来考昔文献

SERCaMP: a carboxy-terminal protein modification that enables monitoring of ER calcium homeostasis.

Mol. Biol. Cell 25(18) , 2828-39, (2014)

Endoplasmic reticulum (ER) calcium homeostasis is disrupted in diverse pathologies, including neurodegeneration, cardiovascular diseases, and diabetes. Temporally defining calcium dysregulation during...

COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells.

Exp. Cell Res. 330(2) , 451-9, (2014)

In the present study, we investigated whether celecoxib could induce the expression of NKG2D ligands in clonogenic colon cancer cells, and increase their susceptibility to NK cell-mediated cell death....

Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms.

Int. J. Oncol. 46(3) , 1393-404, (2015)

Celecoxib plays antitumor roles via multiple mechanisms in a variety of human cancers. The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors. We examined t...

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