海蟾蜍毒素
海蟾蜍毒素用途
Marinobufogenin 是 Na+/K+ ATPase 的高效抑制剂,最初从哺乳动物血浆中鉴定得到。
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海蟾蜍毒素名称
[ CAS 号 ]:
470-42-8
[ 中文名 ]:
海蟾蜍毒素
[ 英文名 ]:
Marinobufogenin
[英文别名 ]:
- Marinobufagenin
- Marinobufogenin
- Marinobufagin
- MARCINOBUFAGIN
- 5-hydroxyl-resibufogenin
海蟾蜍毒素生物活性
[ 描述 ]:
Marinobufogenin 是 Na+/K+ ATPase 的高效抑制剂,最初从哺乳动物血浆中鉴定得到。
[ 相关类别 ]:
[ 靶点 ]
IC50: Na+/K+ ATPase[1]
[参考文献]
海蟾蜍毒素物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
589.0±50.0 °C at 760 mmHg
[ 分子式 ]:
C24H32O5
[ 分子量 ]:
400.508
[ 闪点 ]:
203.0±23.6 °C
[ 精确质量 ]:
400.224976
[ PSA ]:
83.20000
[ LogP ]:
1.25
[ 蒸汽压 ]:
0.0±3.7 mmHg at 25°C
[ 折射率 ]:
1.621
[ 储存条件 ]:
2-8°C，避光，干燥，密封
海蟾蜍毒素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EI2963000
- CHEMICAL NAME :
- 5-beta-Bufa-20,22-dienolide, 3-beta,5-dihydroxy-14,15-beta-epoxy-
- CAS REGISTRY NUMBER :
- 470-42-8
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C24-H32-O5
- MOLECULAR WEIGHT :
- 400.56
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2730 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 152 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 1520 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,111,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 556 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,192,1963
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海蟾蜍毒素安全信息
[ 危害码 (欧洲) ]:
Xi
海蟾蜍毒素上下游产品
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