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藜芦托素

藜芦托素用途

Veratramine 是从 Veratrum californicum 根和根茎中提取的一种甾体生物碱。

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藜芦托素名称

[ CAS 号 ]:
475-00-3

[ 中文名 ]:
藜芦托素

[ 英文名 ]:
Veratrosine

藜芦托素生物活性

[ 描述 ]:

Veratramine 是从 Veratrum californicum 根和根茎中提取的一种甾体生物碱。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Chandler CM, et al. Improved extraction and complete mass spectral characterization of steroidal alkaloids from Veratrum californicum. Nat Prod Commun. 2013 Aug;8(8):1059-64.

藜芦托素物理化学性质

[ 密度 ]:
1.29 g/cm3

[ 沸点 ]:
740.7±60.0℃ at 760 mmHg

[ 熔点 ]:
237.8-239.7℃

[ 分子式 ]:
C₃₃H₄₉NO₇

[ 分子量 ]:
571.74500

[ 精确质量 ]:
571.35100

[ PSA ]:
131.64000

[ LogP ]:
2.74750

[ 蒸汽压 ]:
4.91E-23mmHg at 25°C

[ 储存条件 ]:
2-8℃

藜芦托素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YX7050000

CHEMICAL NAME :: Veratrosine

CAS REGISTRY NUMBER :: 475-00-3

BEILSTEIN REFERENCE NO. :: 0071979

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C33-H49-N-O7

MOLECULAR WEIGHT :: 571.83

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 2,418,1953